PMID: 7543760May 1, 1995Paper

Neuropeptidergic and autonomic control of the vasculature of the rat knee joint revealed by laser Doppler perfusion imaging

Experimental Physiology
S M KarimianW R Ferrell

Abstract

An imaging technique (laser Doppler perfusion imaging, LDI), based on measurement of backscattered Doppler-broadened laser radiation, was used to provide two-dimensional images of perfusion in the exposed rat knee joint capsule. In control animals, frequency-dependent constriction of knee joint blood vessels occurred during electrical stimulation of sympathetic nerve fibres whilst dose-dependent vasodilatation of these vessels was elicited by direct application of the sensory neuropeptide substance P (SP) to the capsule. Intra-articular injection of the neurotoxic agent capsaicin did not affect vasoconstrictor responses when tested 5-7 days later, but substantially reduced dilator responses to SP. These findings indicate that capsaicin is selectively neurotoxic for sensory unmyelinated fibres but not sympathetic postganglionic fibres and is also capable of modifying receptor-mediated effects of SP. LDI is a useful method for mapping tissue perfusion, particularly in structures such as joints where the spatial distribution of blood flow is heterogeneous.

Citations

May 1, 1996·Medical & Biological Engineering & Computing·R BrayW R Ferrell
May 1, 1997·British Journal of Pharmacology·W R FerrellS M Karimian
Dec 15, 2015·CNS Neuroscience & Therapeutics·Milind M MuleyJason J McDougall
Jul 22, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniel MillerRobert C Bray
Jun 14, 2005·Neuroscience Letters·Angelika VargaZsuzsanna Helyes
Dec 28, 2010·Biochimica Et Biophysica Acta·Jason J McDougall
Jun 3, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Éva BorbélyZsuzsanna Helyes
Oct 31, 2007·Arthritis and Rheumatism·H S PalmerW R Ferrell
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Benjamin AndruskiJason J McDougall
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J J McDougall
Feb 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason J McDougall
Dec 9, 2020·British Journal of Pharmacology·Meagan McKenna, Jason J McDougall
Oct 2, 1998·The American Journal of Physiology·J J McDougallD A Hart

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