Neuropeptidergic regulation of pair-bonding and stress buffering: Lessons from voles

Hormones and Behavior
Kyle L Gobrogge, Zuoxin Wang

Abstract

This article is part of a Special Issue "SBN 2014". Interpersonal attachment is a critical component of the human experience. Pair-bonding ameliorates the severity of several mental and physical diseases. Thus, a better understanding of how the central nervous system responds to and encodes social-buffering during stress is a valuable research enterprise. The prairie vole (Microtus ochrogaster), as a laboratory animal model, provides the gold standard for the investigation of the neurobiology underlying attachment. Furthermore, emerging research in voles, additional laboratory rodents, transgenic mice, primates, and humans has provided novel insight into the neurochemical mechanisms underlying the therapeutic effects of social bonds reducing anxiety, depression, and drug abuse liability. In the present review, we highlight the work from this burgeoning field and focus on the role(s) of the neuropeptides oxytocin (OT), vasopressin (AVP), and corticotrophin releasing hormone (CRH) mediating stress buffering. Together, the data suggest that OT underlies social bonding to reduce stress-induced psychological illness while AVP and CRH facilitate arousal to enhance autonomic reactivity, increasing susceptibility to adverse mental and ...Continue Reading

References

Oct 28, 1977·Annals of the New York Academy of Sciences·D A OntjesJ T Gwynne
Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Dec 22, 1990·The Journal of Comparative Neurology·C Decavel, A N Van den Pol
Jan 1, 1987·Annals of the New York Academy of Sciences·L M Bilezikjian, W W Vale
Jul 29, 1988·Science·J S HouseD Umberson
Jan 1, 1987·The American Journal of Drug and Alcohol Abuse·T R KostenH D Kleber
Mar 1, 1995·Journal of Psychiatric Research·H Lüddens, E R Korpi
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·C S CarterL L Getz
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·A C DeVriesC S Carter
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W LovenbergT Oltersdorf
Dec 1, 1993·American Journal of Diseases of Children·D R Wasserman, J M Leventhal
Jan 1, 1996·Critical Reviews in Neurobiology·C Barberis, E Tribollet
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A C DeVriesC S Carter
Jan 1, 1997·Annual Review of Medicine·A RozenzweigC F Reynolds
Jan 15, 1997·Annals of the New York Academy of Sciences·A C DeVriesC S Carter
Apr 6, 1999·International Psychogeriatrics·G J Byrne, B Raphael
May 13, 1999·Neuroscience Letters·M PeterssonK Uvnäs-Moberg
Jul 23, 1999·Annals of the New York Academy of Sciences·D B Carr, S R Sesack
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Jul 7, 2001·Psychological Bulletin·J K Kiecolt-Glaser, T L Newton
Sep 6, 2001·Hormones and Behavior·L J YoungT R Insel

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Citations

May 1, 2016·Biological Psychiatry·Kyle L GobroggeZuoxin Wang
May 2, 2016·Current Opinion in Neurobiology·Kyle Gobrogge, Zuoxin Wang
Oct 21, 2016·American Journal of Primatology·Caroline M HostetlerKaren L Bales
Aug 15, 2018·American Journal of Primatology·Lynea R WitczakKaren L Bales
Sep 28, 2018·Neurotoxicity Research·Evan A BordtMarcy A Kingsbury
Mar 13, 2018·American Journal of Primatology·Jon CavanaughJeffrey A French
Nov 30, 2016·Frontiers in Behavioral Neuroscience·Katie HindeKaren L Bales
Apr 24, 2018·Frontiers in Ecology and Evolution·Nicole ManingerKaren L Bales
Mar 10, 2017·Stress : the International Journal on the Biology of Stress·Neal McNealAngela J Grippo
Jul 25, 2019·Frontiers in Behavioral Neuroscience·Carmen Ferrer-PérezMarta Rodríguez-Arias
Mar 7, 2021·International Journal of Molecular Sciences·Carmen Ferrer-PérezMarta Rodríguez-Arias
Dec 11, 2017·Neuroscience and Biobehavioral Reviews·Yasushi Kiyokawa, Michael B Hennessy

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