PMID: 7520139Apr 11, 1994Paper

Neuropeptides and interleukin-6 in human joint inflammation relationship between intraarticular substance P and interleukin-6 concentrations

Neuroscience Letters
F ArnalichA Hernanz

Abstract

Plasma and synovial fluid concentrations of interleukin-6 (IL-6), using an enzyme-linked immunosorbent assay, as well as immunoreactive levels of calcitonin gene-related peptide (CGRP), substance P and vasoactive intestinal peptide (VIP) were measured in 18 patients with rheumatoid arthritis and 20 with osteoarthritis of the knee. The concentrations of IL-6 were elevated in both plasma and synovial fluids from patients with rheumatoid arthritis whereas higher levels of substance P-, CGRP- and VIP-like immunoreactivities were found in the synovial fluid, but not in plasma, from patients with rheumatoid arthritis when compared with those in osteoarthritis. Furthermore, IL-6 and substance P levels in synovial fluid were significantly correlated both in rheumatoid arthritis and osteoarthritis patients. Our data seem to support the idea of an important role shared by neuropeptides and IL-6 in the pathogenesis of human inflammatory joint disease.

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Citations

Jun 20, 1994·Neuroscience Letters·E De MiguelA Hernanz
Dec 14, 2002·Brain, Behavior, and Immunity·Paul H Black
Jun 13, 2000·American Journal of Veterinary Research·C A Kirker-HeadM S Kumar
Nov 22, 2015·Arthritis Research & Therapy·Matthias EbbinghausHans-Georg Schaible
May 2, 2008·Expert Opinion on Investigational Drugs·Simon J Read, Andy Dray
Jan 5, 2001·Expert Opinion on Investigational Drugs·S Brunelleschi
Aug 25, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B O LjungJ Fridén
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P StashenkoR D'Souza
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Björn-Ove LjungSture Forsgren
Feb 2, 2006·Zeitschrift für Rheumatologie·W MüllerT Stratz
May 24, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M Carrozzo, S Gandolfo
Jul 23, 2013·Spine·Christopher K KeplerD Greg Anderson
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Jun 15, 1997·Medizinische Klinik·T GeilerB Manger
Oct 3, 2020·Mediators of Inflammation·Yanting CaoYiqing Yin
Jan 11, 2005·Rheumatic Diseases Clinics of North America·Hans-Georg SchaibleMarco Matucci-Cerinic

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