Neuropeptides and polypeptide hormones in echinoderms: new insights from analysis of the transcriptome of the sea cucumber Apostichopus japonicus

General and Comparative Endocrinology
Matthew RoweMaurice R Elphick

Abstract

Echinoderms are of special interest for studies in comparative endocrinology because of their phylogenetic position in the animal kingdom as deuterostomian invertebrates. Furthermore, their pentaradial symmetry as adult animals provides a unique context for analysis of the physiological and behavioral roles of peptide signaling systems. Here we report the first extensive survey of neuropeptide and peptide hormone precursors in a species belonging to the class Holothuroidea. Transcriptome sequence data obtained from the sea cucumber Apostichopus japonicus were analyzed to identify homologs of precursor proteins that have recently been identified in the sea urchin Strongylocentrotus purpuratus (class Echinoidea). A total of 17 precursor proteins have been identified in A. japonicus, including precursors of peptides related to thyrotropin-releasing hormone, pedal peptide/orcokinin-type peptides, AN peptides/tachykinins, luqins, corticotropin-releasing hormone (CRH), GPA2-type glycoprotein hormone subunits and bursicon. In addition, an unusual finding was an A. japonicus calcitonin-type precursor protein (AjCTLPP), the first to be discovered that comprises two calcitonin-like peptides; this contrasts with the products of the altern...Continue Reading

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Citations

Mar 4, 2014·General and Comparative Endocrinology·Maurice R Elphick
Jan 24, 2016·Journal of Neurochemistry·Chan-Hee KimNam Gyu Park
Jul 6, 2014·Frontiers in Endocrinology·Maurice R Elphick, Olivier Mirabeau
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Dec 18, 2018·Frontiers in Endocrinology·Toshio Sekiguchi
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Mar 7, 2020·Frontiers in Neuroscience·Luis Alfonso Yañez-Guerra, Maurice R Elphick
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May 10, 2018·Scientific Reports·Luis Alfonso Yañez-GuerraMaurice R Elphick
Oct 12, 2020·General and Comparative Endocrinology·Iván LazcanoJean-Louis Charli

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