PMID: 9544784Apr 17, 1998Paper

Neuropeptides in the livers of mice during bacterial infections

FEMS Immunology and Medical Microbiology
A NakaneT Minagawa

Abstract

Neuropeptides such as substance P (SP) and vasoactive intestinal peptide (VIP) are known to act as immunomodulators. We investigated the induction of SP and VIP in the livers of mice infected with Listeria monocytogenes or injected with Tsukamurella paurometabolum. VIP was detected in the livers of mice after L. monocytogenes infection by an immunohistochemical technique and preproVIP mRNA, which was detected by reverse transcription-polymerase chain reaction (PCR), was induced post infection. However, no SP was detected. In contrast, SP, but not VIP was detected within granulomas in the livers of T. paurometabolum-injected mice, suggesting VIP and SP might be selectively induced in the liver by different bacterial infections.

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H W RogersR D Schreiber
Jun 1, 1987·Immunology and Cell Biology·R D HelmeC S Hosking
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A Buchmeier, R D Schreiber
Jun 30, 1980·Biochemical and Biophysical Research Communications·Z Bar-ShavitS Blumberg
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·E HirschD Hirsh

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Citations

Feb 11, 2009·Critical Reviews in Toxicology·Anne KorpiAnna-Liisa Pasanen
Dec 2, 2010·SAR and QSAR in Environmental Research·G PatlewiczE M Donner
Sep 5, 2014·Nihon saikingaku zasshi. Japanese journal of bacteriology·Akio Nakane

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