Neuropeptides responding to leptin

Nutrition Reviews
G Wolf

Abstract

Leptin, the circulating protein that inhibits food intake and energy expenditure, was thought to function through inhibition of the hypothalamic neuropeptide Y (NPY), a stimulator of food intake. However, mouse mutants lacking NPY are normal, suggesting that alternative neuromodulators of food intake must exist. Recently, melanocortin, a neuropeptide acting on the hypothalamic receptor melanocortin4-R, was discovered in mice, controlling energy regulation. This receptor is antagonized by the "agouti" protein in the mutant obese agouti mouse.

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Citations

Jun 17, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A da SilvaJohn E Hall
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