Neuropeptidomics: Improvements in Mass Spectrometry Imaging Analysis and Recent Advancements.

Current Protein & Peptide Science
Nhu Q VuLingjun Li

Abstract

Neuropeptides are an important class of endogenous peptides in the nervous system that regulate physiological functions such as feeding, glucose homeostasis, pain, memory, reproduction, and many others. In order to understand the functional role of neuropeptides in diseases or disorders, studies investigating their dysregulation in terms of changes in abundance and localization must be carried out. As multiple neuropeptides are believed to play a functional role in each physiological process, techniques capable of global profiling multiple neuropeptides simultaneously are desired. Mass spectrometry is well-suited for this goal due to its ability to perform untargeted measurements without prior comprehensive knowledge of the analytes of interest. Mass spectrometry imaging (MSI) is particularly useful because it has the capability to image a large variety of peptides in a single experiment without labeling. Like all analytical techniques, careful sample preparation is critical to successful MSI analysis. The first half of this review focuses on recent developments in MSI sample preparation and instrumentation for analyzing neuropeptides and other biomolecules in which the sample preparation technique may be directly applicable fo...Continue Reading

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Citations

Jun 11, 2021·Journal of the American Society for Mass Spectrometry·William T AndrewsAmanda B Hummon
May 18, 2021·Current Protein & Peptide Science·Timothy Veenstra

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