PMID: 6112273Jun 1, 1980Paper

Neuropharmacological agents modifying endotoxin-induced changes in mice

Journal of the Royal Society of Medicine
D J Wright, M P Weller

Abstract

A variety of neuropharmacological agents were tested to elucidate how chlorpromazine influenced an endotoxin-induced reaction. The results obtained, particularly with beta-adrenergic blocking agents, reserpine and fusaric acid, suggested that the primary locus of chlorpromazine's action was mediated by peripheral beta-adrenergic receptor blockade. Such a locus is compatible with the low doses of propranolol which suppress the reaction, and with successful treatment of shock with dopamine.

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