Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice

Journal of Ethnopharmacology
A L MartínezM E González-Trujano

Abstract

Magnolia dealbata Zucc. is considered to have tranquilizer and anticonvulsant properties in Mexican traditional medicine. In the present study we report the effects of a crude extract of Magnolia dealbata (30, 100 and 300 mg/kg) on mouse central nervous system (CNS). Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs. No changes in spontaneous locomotor activity were produced posterior to Magnolia dealbata administration; however, a significant and dose-dependent diminution in the anxiety response was observed in experimental models such as plus-maze, head-dipping and exploratory rearing tests. Magnolia dealbata not only prolonged the time of sodium pentobarbital-induced hypnosis and delayed the onset of PTZ-induced mioclonus and clonus, but also hindered the presence of tonic seizures and avoided mortality. The hypnotic, anxiolytic and anticonvulsant effects obtained in these experiments support the hypothesis that Magnolia dealbata possesses CNS activity and reinforces the popular use in Mexican traditional medicine.

Citations

Mar 1, 2012·Archives of Pharmacal Research·Jae-Wook KimKi-Wan Oh
Feb 19, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Jae-Wook KimKi-Wan Oh
Jun 9, 2012·Behavioural Brain Research·Lee David Ellis, Kelly Howard Soanes
Apr 23, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Angel Josabad Alonso-CastroLuis A Salazar-Olivo
Dec 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qun XuLing-Dong Kong
Mar 30, 2016·Journal of Ethnopharmacology·Carolina López-Rubalcava, Erika Estrada-Camarena
Jan 10, 2014·Pharmaceutical Biology·Angel Josabad Alonso-CastroAlejandro García-Carrancá
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Aug 5, 2017·Metabolic Brain Disease·Muhammad Ali RajputTahira Assad
Apr 16, 2013·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Norma Flores-EstévezFrancisco Díaz-Fleischer
Apr 19, 2013·Free Radical Research·C Guerra-AraizaH Salgado-Ceballos
Mar 21, 2020·Current Pharmaceutical Design·Angélica Vega-GarcíaSandra Orozco-Suarez
Dec 22, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yunlai ZhiKun Yang

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