Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice

Journal of Ethnopharmacology
A L MartínezM E González-Trujano


Magnolia dealbata Zucc. is considered to have tranquilizer and anticonvulsant properties in Mexican traditional medicine. In the present study we report the effects of a crude extract of Magnolia dealbata (30, 100 and 300 mg/kg) on mouse central nervous system (CNS). Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs. No changes in spontaneous locomotor activity were produced posterior to Magnolia dealbata administration; however, a significant and dose-dependent diminution in the anxiety response was observed in experimental models such as plus-maze, head-dipping and exploratory rearing tests. Magnolia dealbata not only prolonged the time of sodium pentobarbital-induced hypnosis and delayed the onset of PTZ-induced mioclonus and clonus, but also hindered the presence of tonic seizures and avoided mortality. The hypnotic, anxiolytic and anticonvulsant effects obtained in these experiments support the hypothesis that Magnolia dealbata possesses CNS activity and reinforces the popular use in Mexican traditional medicine.


Mar 1, 2012·Archives of Pharmacal Research·Jae-Wook KimKi-Wan Oh
Feb 19, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Jae-Wook KimKi-Wan Oh
Jun 9, 2012·Behavioural Brain Research·Lee David Ellis, Kelly Howard Soanes
Apr 23, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Angel Josabad Alonso-CastroLuis A Salazar-Olivo
Dec 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qun XuLing-Dong Kong
Mar 30, 2016·Journal of Ethnopharmacology·Carolina López-Rubalcava, Erika Estrada-Camarena
Jan 10, 2014·Pharmaceutical Biology·Angel Josabad Alonso-CastroAlejandro García-Carrancá
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Aug 5, 2017·Metabolic Brain Disease·Muhammad Ali RajputTahira Assad
Apr 16, 2013·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Norma Flores-EstévezFrancisco Díaz-Fleischer
Apr 19, 2013·Free Radical Research·C Guerra-AraizaH Salgado-Ceballos
Mar 21, 2020·Current Pharmaceutical Design·Angélica Vega-GarcíaSandra Orozco-Suarez
Dec 22, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yunlai ZhiKun Yang

Related Concepts

Dose-Response Relationship, Drug
Lethal Dose 50
Plant Extracts
Non-epileptic Convulsion

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.