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Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology

Neuroscience and Biobehavioral Reviews

Nov 14, 1997

John H McDonough, T M Shih

PMID: 9353792

Abstract

This paper proposes a three phase "model" of the neuropharmacological processes responsible for the seizures and neuropathology produced by nerve agent intoxication. Initiation and early expression of the seizures are cholinergic phenomenon; anticholinergics readily terminate seizures a...read more

Mentioned in this Paper

Anticholinergic mydriatics and cycloplegics
Calcium [EPC]
Anticonvulsants
Calcium
Anticholinergics inhalants for obstructive airway diseases
Transcription Initiation
Cholinesterase Inhibitors, Reversible
N-Methylaspartate
Anticholinergic [EPC]
Neuropathology
61
Paper Details
References
  • References128
  • Citations447
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  • References128
  • Citations447
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Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology

Neuroscience and Biobehavioral Reviews

Nov 14, 1997

John H McDonough, T M Shih

PMID: 9353792

DOI:

Abstract

This paper proposes a three phase "model" of the neuropharmacological processes responsible for the seizures and neuropathology produced by nerve agent intoxication. Initiation and early expression of the seizures are cholinergic phenomenon; anticholinergics readily terminate seizures a...read more

Mentioned in this Paper

Anticholinergic mydriatics and cycloplegics
Calcium [EPC]
Anticonvulsants
Calcium
Anticholinergics inhalants for obstructive airway diseases
Transcription Initiation
Cholinesterase Inhibitors, Reversible
N-Methylaspartate
Anticholinergic [EPC]
Neuropathology
61

Similar Papers Found In These Feeds

NMDA Receptor Signaling

The NDMA receptor is an ionotropic receptor that is activated when glutamate or glycine binds to it, initiating several downstream signaling cascades. NDMA receptor signaling is thought to be implicated in different pathologies, including depression. Here is the latest research on NDMA receptor signaling.

Neurotransmitters

Neurotransmitters are released from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind specific receptors in order to bring about changes in postsynaptic neurons. Here is the latest research.

Related Papers

Neuroscience and Biobehavioral Reviews

Pharmacological modulation of soman-induced seizures

Neuroscience and Biobehavioral ReviewsJanuary 1, 1993
John H McDonough, T M Shih
Toxicology and Applied Pharmacology

Control of nerve agent-induced seizures is critical for neuroprotection and survival

Toxicology and Applied PharmacologyApril 15, 2003
Tsung-Ming ShihJohn H McDonough
Paper Details
References
  • References128
  • Citations447
12345...
  • References128
  • Citations447
12345...
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