PMID: 6109351Jan 1, 1980Paper

Neuropharmacological studies of phencyclidine (PCP)-induced behavioral stimulation in mice

Psychopharmacology
W J FreedR J Wyatt

Abstract

A variety of drugs were screened to determine which were capable of blocking the behavioral stimulation produced in mice by acute administration of phencyclidine (PCP). Chlorpromazine and clozapine blocked PCP-induced stimulation, while haloperidol, reserpine, and alpha-methyl-p-tyrosine did not. The GABA receptor agonists imidazole acetic acid and muscimol blocked PCP, but other drugs that influence GABA, such as dipropylacetic acid, baclofen, and diazepam, were ineffective. Yohimbine and methysergide also blocked PCP in high dosages, but other drugs with comparable alpha-noradrenergic and serotonergic blocking properties (phentolamine, cyproheptadine, and cinnanserin) were ineffective. Cholinergic and anticholinergic drugs, beta-noradrenergic and opiate antagonists and nonspecific sedatives and convulsants were also ineffective. These findings suggest that chlorpromazine, clozapine, yohimbine, and methysergide may share a property that is unlike their primary known modes of action on dopaminergic, alpha-noradrenergic, and serotonergic neurotransmitter systems, and that this property accounts for their ability to block PCP. However, the effectiveness of GABA agonists appears to be mediated through direct activation of GABA rec...Continue Reading

References

Dec 1, 1978·European Journal of Pharmacology·R F SchlemmerJ M Davis
Sep 1, 1978·Annals of Neurology·I ShoulsonR J Joynt
Jul 15, 1975·Life Sciences·E CostaA Suria
Aug 1, 1976·Neuropharmacology·S R NaikE Costa
Jun 1, 1978·The American Journal of Psychiatry·C A TammingaT N Chase
Sep 1, 1978·The American Journal of Psychiatry·R M Allen, S J Young
Feb 1, 1979·The American Journal of Psychiatry·H Y MeltzerD Sturgeon
Jan 1, 1976·Clinical Toxicology·R S Burns, S E Lerner
Nov 1, 1977·The American Journal of Psychiatry·C V Showalter, W E Thornton
Jan 1, 1976·Clinical Toxicology·P V Luisada, B I Brown
Oct 11, 1975·The American Journal of Psychiatry·J M Rainey, M K Crowder
Oct 24, 1975·Brain Research·K SaitoM Otsuka
Nov 13, 1975·JAMA : the Journal of the American Medical Association·C B LidenC E Costello
Feb 1, 1974·European Journal of Pharmacology·Z PasterM Sokolovsky
Dec 14, 1974·British Medical Journal·N J YorkstonC W Havard
Oct 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·B E Leonard, S R Tonge

❮ Previous
Next ❯

Citations

Jan 1, 1991·Journal of Neural Transmission. General Section·A LecciA Meli
Jan 1, 1995·Journal of Neural Transmission. General Section·I M WhiteG V Rebec
Jan 1, 1987·Journal of Neural Transmission·J A GrebbW J Freed
Nov 19, 1981·European Journal of Pharmacology·R D SturgeonH Y Meltzer
Jan 1, 1992·Life Sciences·I P Lapin, M A Rogawski
Jul 1, 1984·Pharmacology, Biochemistry, and Behavior·W J FreedD V Jeste
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·G C WagnerA Tomie
Nov 1, 1987·Pharmacology, Biochemistry, and Behavior·C A WilmotM T Spoerlein
Apr 1, 1987·Pharmacology, Biochemistry, and Behavior·D J CalcagnettiD L Margules
Apr 1, 1987·Pharmacology, Biochemistry, and Behavior·J L CadetW J Freed
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·N Seiler, C Grauffel
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·R E SteinpreisJ D Salamone
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·R Corbett
Jun 1, 1990·Trends in Pharmacological Sciences·H Wachtel, L Turski
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Ratna Sircar, Karam F A Soliman
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·R E SteinpreisC K Kruschel
Oct 29, 1998·General Pharmacology·G Tunnicliff
Mar 1, 1986·Neurochemical Research·E Toth, A Lajtha
Jan 1, 1986·Medicinal Research Reviews·W H Soine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here