Neurophysiologic evaluation of cyclosporine toxicity associated with bone marrow transplantation

Acta Neurologica Scandinavica
L L EdwardsM M Normand

Abstract

Cortical blindness, a rare form of cyclosporine (CSA) neurotoxicity, has previously been described in only nine bone marrow transplant (BMT) recipients. Our institutions averages 35 allogeneic BMT's per year. In the past year we have seen two women with reversible cortical blindness secondary to CSA toxicity. Age (years) (Case 1; Case 2): 32; 22. Day post-BMT: 41: 50. Peak CSA level (ng/ml): 1159; 632. Both had a history of renal toxicity requiring adjustment of CSA dosage. MRI - both with diffuse white matter changes. EEG-both with moderate to severe generalized slowing. Visual evoked potentials were markedly prolonged in both. Auditory evoked potentials: minimally abnormal; normal. Somatosensory evoked potential - both normal. Prompt improvement occurred with discontinuation of CSA. Followup neurophysiologic evaluations were normal, however structural changes remain on MRI. As neurophysiologic studies closely follow the clinical status they should be included in the evaluation and followup of CSA neurotoxicity.

References

Jun 13, 1991·The New England Journal of Medicine·F GottrandJ P Farriaux
Oct 1, 1987·The New England Journal of Medicine·P C de GroenR A Krom
Mar 24, 1988·The New England Journal of Medicine
Mar 30, 1985·British Medical Journal·R J PolsonR Williams
Oct 9, 1982·Lancet·S DurrantE C Gordon-Smith
Nov 27, 1982·Lancet·M A BoogaertsR L Verwilghen
Nov 27, 1982·Lancet·H Dieperink, J Møller
Nov 17, 1984·Lancet·C B ThompsonE D Thomas
Mar 1, 1984·Archives of Neurology·R B Noll, R Kulkarni
Dec 1, 1981·Transplantation·G B KlintmalmT E Starzl

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

Neurología : publicación oficial de la Sociedad Española de Neurología
V BertolC Almarcegui
Neurología : publicación oficial de la Sociedad Española de Neurología
R de la Fuente FernándezJ Graña Gil
Revista de medicina de la Universidad de Navarra
T SagalésV Gimeno
© 2021 Meta ULC. All rights reserved