Neurophysiologic evaluation of cyclosporine toxicity associated with bone marrow transplantation

Acta Neurologica Scandinavica
L L EdwardsM M Normand

Abstract

Cortical blindness, a rare form of cyclosporine (CSA) neurotoxicity, has previously been described in only nine bone marrow transplant (BMT) recipients. Our institution averages 35 allogeneic BMT's per year. In the past year we have seen two women with reversible cortical blindness secondary to CSA toxicity. Age (years) (Case 1; Case 2): 32; 22. Day post-BMT: 41; 50. Peak CSA level (ng/ml): 1159; 632. Both had a history of renal toxicity requiring adjustment of CSA dosage. MRI - both with diffuse while matter changes. EEG - both with moderate to severe generalized slowing. Visual evoked potentials were markedly prolonged in both. Auditory evoked potentials: minimally abnormal; normal. Somatosensory evoked potentials - both normal. Prompt improvement occurred with discontinuation of CSA. Followup neurophysiologic evaluations were normal, however structural changes remained on MRI. As neurophysiologic studies closely follow the clinical status they should be included in the evaluation and followup of CSA neurotoxicity.

References

Jun 13, 1991·The New England Journal of Medicine·F GottrandJ P Farriaux
Oct 1, 1987·The New England Journal of Medicine·P C de GroenR A Krom
Mar 24, 1988·The New England Journal of Medicine
Mar 30, 1985·British Medical Journal·R J PolsonR Williams
Oct 9, 1982·Lancet·S DurrantE C Gordon-Smith
Nov 27, 1982·Lancet·M A BoogaertsR L Verwilghen
Nov 27, 1982·Lancet·H Dieperink, J Møller
Nov 17, 1984·Lancet·C B ThompsonE D Thomas
Mar 1, 1984·Archives of Neurology·R B Noll, R Kulkarni
Dec 1, 1981·Transplantation·G B KlintmalmT E Starzl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.