PMID: 9650683Jul 3, 1998Paper

Neurophysiologic evaluation of long-term desferrioxamine therapy in beta-thalassemia patients

Pediatric Neurology
Dimitrios I ZafeiriouM A Athanasiou

Abstract

Forty patients with beta-thalassemia major (BTM), between 11 and 19 years of age and maintained on long-term desferrioxamine (DFO) treatment, were examined by evoked potential and nerve conduction velocity studies to investigate a possible involvement of the auditory, visual, somatosensory, or peripheral nervous pathways. Pathologic findings in brainstem auditory-, visual-, and somatosensory-evoked potentials, and nerve conduction velocity studies were demonstrated in 25%, 15%, 7.5%, and 25% of the patients, respectively, whereas 15% demonstrated involvement of multiple neural pathways. Subclinical involvement of the auditory pathway was statistically associated with higher mean daily DFO dose and longer duration of DFO therapy, whereas abnormalities regarding the somatosensory pathways were related to older age, longer mean duration of DFO therapy, and lower serum copper levels. Involvement of the peripheral nervous system was related to lower serum copper levels. Multiple involvement of neural pathways was related to longer mean duration of DFO therapy. We conclude that risk factors related to long-term DFO treatment are only partly responsible for the subclinical involvement of neural pathways demonstrated in beta-thalassemi...Continue Reading

References

Dec 15, 1989·American Journal of Ophthalmology·S GartaganisD Papanastasiou
Apr 6, 1985·Lancet·M RubinsteinJ Hainaut
Jan 1, 1989·Archives of Disease in Childhood·B WonkeP Warner
Apr 3, 1986·The New England Journal of Medicine·N F OlivieriB Skarf
Jul 23, 1983·Lancet·S C DaviesE R Huehns
Aug 27, 1983·Lancet·P SimonY Mauras
Mar 24, 1984·Lancet·C Borgna-PignattiA M Broglia
May 1, 1996·International Journal of Pediatric Otorhinolaryngology·G KontzoglouM Athanassiou

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Citations

Jun 5, 2001·The British Journal of Radiology·Z MetafratziS C Efremidis
Jun 1, 2005·Brain & Development·Marina EconomouMiranda Athanassiou-Metaxa
Mar 4, 2008·Scandinavian Journal of Medicine & Science in Sports·S NanasA Aessopos
Apr 24, 2015·Annals of Hematology·P NemtsasA Orologas
Feb 11, 2018·Annals of Hematology·P NemtsasA Orologas
Oct 23, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Ozgur DumanVolkan Hazar
Feb 11, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Aikaterini TeliDimitrios Zafeiriou
Oct 12, 2019·International Ophthalmology·Samira HeydarianMehdi Khabazkhoob
Jun 3, 2004·Annals of Neurology·Dimitrios I ZafeiriouFenella J Kirkham
Aug 8, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mona H El-TaguiAmina Abdel-Salam
Feb 6, 2021·Neuroscience and Biobehavioral Reviews·Deborah ChiabrandoEmanuela Tolosano
Apr 1, 2006·Brain & Development·Dimitrios I ZafeiriouMiranta Athanasiou-Metaxa

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