PMID: 2110371Jan 1, 1990Paper

Neurophysiological and biochemical changes evoked by valproic acid in the central nervous system

Progress in Neurobiology
D CotariuS Evans

Abstract

(1) Valproic acid is an anticonvulsant agent widely used in the management of various forms of epilepsy, including absence, myoclonic and tonic-clonic seizures. (2) It also has anticonvulsant potency in a wide variety of animal models of epilepsy. (3) This action is generally thought to be exerted through modulation of the activity of the endogenous inhibitory neurotransmitter, gamma-aminobutyric acid. (4) Evidence that valproic acid interacts with the gamma-aminobutyric acid system is presented. (5) Interactions of valproic acid with other neurotransmitters, i.e. aspartate, glutamate, taurine, serotonin, as well as with cyclic nucleotides and hormones are also considered. (6) Direct effects of valproic acid on excitable membranes and its relationships with analgesia are outlined.

Citations

Oct 27, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Andrew M GellerWilliam K Boyes
Feb 17, 1992·Neuroscience Letters·M NilssonE Hansson
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Jan 5, 2000·Neuroscience Research·S A Otoom, K A Alkadhi
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