Abstract
The effects, in rats, of peripherally administered capsaicin were evaluated on body temperature and on brain neurophysiological activity. Capsaicin (5 mg/kg, SC) produced a rapid, long-lasting fall in body temperature. A second dose given 4.5 hr after the first showed a moderate decrement in hypothermic effect. The same dose of capsaicin caused discernible changes in deep EEG activity in the anterior hypothalamus (AH), medial habenula (HB), substantia nigra (SN), and dorsal raphe (DR). The EEG changes were more pronounced at doses of 10 and 20 mg/kg. Capsaicin in all doses modified sensory evoked responses recorded from all four brain areas. Response amplitudes after acoustic stimulation were increased at all doses of capsaicin in a dose related pattern. Photic evoked responses, like body temperature effects, showed diminished effects with second and third doses. Peripherally administered capsaicin, therefore, can affect body temperature and brain electrical activity.
References
Oct 8, 1979·Life Sciences·R M Virus, G F Gebhart
Aug 18, 1978·Brain Research·T M JessellA C Cuello
Oct 26, 1979·Science·T L YakshT M Jessell
Mar 1, 1978·The Journal of Comparative Neurology·A C Cuello, I Kanazawa
Jul 6, 1979·Brain Research·E TheriaultT Jessell
Apr 1, 1978·Experimental Neurology·N Dafny
Oct 1, 1978·Neuropharmacology·N Dafny, B M Rigor
Nov 5, 1976·Brain Research·M J BrownsteinS E Leeman
Sep 1, 1976·Neuropharmacology·N Dafny, T F Burks
Jan 1, 1975·Neuroendocrinology·N Dafny
Mar 1, 1970·The Journal of Physiology·A Jancsó-GáborN Jancsó
Jun 1, 1970·The Journal of Physiology·A Jancsó-GáborN Jancsó
Citations
Dec 1, 1991·Synapse·S Caldecott-HazardD Janowsky
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·B Dib
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·R G BurrightZ Dolinsky
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·J R Mason, J A Maruniak
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R J BodnarG Nilaver
Jul 1, 1992·Neuroscience·J ToldiJ R Wolfe
Dec 16, 2003·Brain Research·Jennifer C RobertsChristopher D Benham
Sep 28, 2000·Trends in Neurosciences·A Szallasi, V Di Marzo
Mar 12, 1997·Regulatory Peptides·N WeigertV Schusdziarra
Jan 1, 1991·Critical Reviews in Food Science and Nutrition·V S Govindarajan, M N Sathyanarayana
Sep 15, 2009·Pharmacological Reviews·Andrej A RomanovskyTatiane B Nucci
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·H A RingE H Reynolds
Sep 23, 2008·Trends in Pharmacological Sciences·Narender R Gavva
Dec 25, 2007·Neuroscience Letters·Zhe DingScott M Rawls
Jan 16, 2004·The Journal of Physiology·Consuelo Morgado-Valle, Jack L Feldman
Jun 3, 2014·Neuropharmacology·D MartinsC Morgado
Dec 4, 2014·Autonomic Neuroscience : Basic & Clinical·Jing DongJijian Zheng
Jul 6, 2000·The Journal of Comparative Neurology·C O OkereT Higuchi
Oct 1, 1982·Critical Reviews in Toxicology·Y MonsereenusornP D Pezalla
Nov 10, 2006·Molecular Pain·Hendrik W SteenlandMin Zhuo
Mar 17, 2007·International Journal of Toxicology
May 1, 1986·British Journal of Industrial Medicine·S ArakiH Aono
Jul 1, 1983·British Journal of Pharmacology·J Donnerer, F Lembeck