PMID: 6162532Nov 1, 1980Paper

Neurophysiological and thermoregulatory effects of capsaicin

Brain Research Bulletin
L S RabeN Dafny

Abstract

The effects, in rats, of peripherally administered capsaicin were evaluated on body temperature and on brain neurophysiological activity. Capsaicin (5 mg/kg, SC) produced a rapid, long-lasting fall in body temperature. A second dose given 4.5 hr after the first showed a moderate decrement in hypothermic effect. The same dose of capsaicin caused discernible changes in deep EEG activity in the anterior hypothalamus (AH), medial habenula (HB), substantia nigra (SN), and dorsal raphe (DR). The EEG changes were more pronounced at doses of 10 and 20 mg/kg. Capsaicin in all doses modified sensory evoked responses recorded from all four brain areas. Response amplitudes after acoustic stimulation were increased at all doses of capsaicin in a dose related pattern. Photic evoked responses, like body temperature effects, showed diminished effects with second and third doses. Peripherally administered capsaicin, therefore, can affect body temperature and brain electrical activity.

References

Aug 18, 1978·Brain Research·T M JessellA C Cuello
Mar 1, 1978·The Journal of Comparative Neurology·A C Cuello, I Kanazawa
Jul 6, 1979·Brain Research·E TheriaultT Jessell
Oct 1, 1978·Neuropharmacology·N Dafny, B M Rigor
Nov 5, 1976·Brain Research·M J BrownsteinS E Leeman
Jan 1, 1975·Neuroendocrinology·N Dafny

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Citations

Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·B Dib
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·R G BurrightZ Dolinsky
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·J R Mason, J A Maruniak
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R J BodnarG Nilaver
Sep 28, 2000·Trends in Neurosciences·A Szallasi, V Di Marzo
Sep 15, 2009·Pharmacological Reviews·Andrej A RomanovskyTatiane B Nucci
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·H A RingE H Reynolds
Sep 23, 2008·Trends in Pharmacological Sciences·Narender R Gavva
Dec 25, 2007·Neuroscience Letters·Zhe DingScott M Rawls
Jan 16, 2004·The Journal of Physiology·Consuelo Morgado-Valle, Jack L Feldman
Jun 3, 2014·Neuropharmacology·D MartinsC Morgado
Oct 1, 1982·Critical Reviews in Toxicology·Y MonsereenusornP D Pezalla
Nov 10, 2006·Molecular Pain·Hendrik W SteenlandMin Zhuo
Jul 1, 1983·British Journal of Pharmacology·J Donnerer, F Lembeck

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