Neurophysiological Evidence of Compensatory Brain Mechanisms in Early-Stage Multiple Sclerosis

PloS One
Mariana López-GóngoraJordi Riba

Abstract

Multiple sclerosis (MS) is a chronic central nervous system disorder characterized by white matter inflammation, demyelination and neurodegeneration. Although cognitive dysfunction is a common manifestation, it may go unnoticed in recently-diagnosed patients. Prior studies suggest MS patients develop compensatory mechanisms potentially involving enhanced performance monitoring. Here we assessed the performance monitoring system in early-stage MS patients using the error-related negativity (ERN), an event-related brain potential (ERP) observed following behavioral errors. Twenty-seven early-stage MS patients and 31 controls were neuropsychologically assessed. Electroencephalography recordings were obtained while participants performed: a) a stop task and b) an auditory oddball task. Behavior and ERP measures were assessed. No differences in performance were found between groups in most neuropsychological tests or in behavior or ERP components in the auditory oddball task. However, the amplitude of the ERN associated with stop errors in the stop task was significantly higher in patients. ERN amplitude correlated positively with scores on the Expanded Disability Status Scale and the Multiple Sclerosis Severity Score, and negativel...Continue Reading

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Citations

Jul 3, 2020·Multiple Sclerosis : Clinical and Laboratory Research·C ThrueU Dalgas
Dec 12, 2018·Journal of Clinical and Experimental Neuropsychology·Anne-Marie TernesJoanne Fielding
May 29, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Gabriele PasquaPatrizia Pantano
Feb 13, 2021·Neuropsychiatric Disease and Treatment·Elizabeth S Gromisch, Zaenab Dhari
Mar 23, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pierfilippo De SanctisJohn J Foxe
Mar 12, 2021·Brain : a Journal of Neurology·Reza RahmanzadehCristina Granziera

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