Neurophysiological features in relation to clinical signs in clinically diagnosed corticobasal degeneration

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
D MonzaF Girotti

Abstract

We investigated the association between clinical and neurophysiological characteristics in patients with a clinical diagnosis of probable corticobasal degeneration (CBD), and searched for neurophysiological features supporting the diagnosis in life. Ten patients with clinically probable CBD underwent comprehensive neurological evaluation and brain MRI. Long latency reflexes (LLR), upper limb somatosensory (SEP) and motor evoked (MEP) potentials were recorded. The mini-mental state examination (MMSE), the phonemic verbal fluency test (PVFT) and the De Renzi ideomotor apraxia test were also performed. Polygraphic EEG was performed in the six patients with myoclonus. The SEP N30 frontal component was absent bilaterally in four patients, was absent on the left side in one, and had increased latency in other three. MEPs were abnormal in four patients (three had prolonged central motor conduction time, one of whom also had increased MEP threshold, and one had increased MEP threshold). All six patients with myoclonus had enhanced LLRs at rest, which were also of abnormally increased amplitude during motor activation; latencies were generally shorter than in classic cortical reflex myoclonus. On back-averaging, no EEG spikes time-locke...Continue Reading

Citations

Dec 17, 2008·Neuropsychology Review·Vessela StamenovaSandra E Black
Oct 23, 2008·Brain : a Journal of Neurology·Emmanuelle ApartisAnnie Lannuzel
Jun 19, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Abdul Qayyum RanaIshraq Siddiqui
Mar 24, 2009·Parkinsonism & Related Disorders·W J G van de WassenbergN M Maurits
Nov 10, 2006·IEEE Transactions on Visualization and Computer Graphics·Michael ten CaatJos B T M Roerdink
Jan 8, 2018·Journal of Neurology·Aditya A Murgai, Mandar S Jog
Jun 3, 2005·Brain : a Journal of Neurology·Cindy Zadikoff, Anthony E Lang

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