Neurophysiological signatures of hand motor response to dual-transcranial direct current stimulation in subacute stroke: a TMS and MEG study

Journal of Neuroengineering and Rehabilitation
I-Ju KuoI-Hui Lee

Abstract

Dual transcranial direct current stimulation (tDCS) to the bilateral primary motor cortices (M1s) has potential benefits in chronic stroke, but its effects in subacute stroke, when behavioural effects might be expected to be greater, have been relatively unexplored. Here, we examined the neurophysiological effects and the factors influencing responsiveness of dual-tDCS in subacute stroke survivors. We conducted a randomized sham-controlled crossover study in 18 survivors with first-ever, unilateral subcortical ischaemic stroke 2-4 weeks after stroke onset and 14 matched healthy controls. Participants had real dual-tDCS (with an ipsilesional [right for controls] M1 anode and a contralesional M1 [left for controls] cathode; 2 mA for 20mins) and sham dual-tDCS on separate days, with concurrent paretic [left for controls] hand exercise. Using transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG), we recorded motor evoked potentials (MEPs), the ipsilateral silent period (iSP), short-interval intracortical inhibition, and finger movement-related cortical oscillations before and immediately after tDCS. Stroke survivors had decreased excitability in ipsilesional M1 with a relatively excessive transcallosal inhibition...Continue Reading

References

Nov 1, 1993·The Journal of Physiology·T KujiraiC D Marsden
Jan 1, 1994·Medical & Biological Engineering & Computing·M S Hämäläinen, R J Ilmoniemi
Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
Feb 15, 2002·Brain : a Journal of Neurology·Friedhelm HummelChristian Gerloff
Dec 4, 2003·Epilepsia·G Pfurtscheller
Jan 7, 2005·Brain : a Journal of Neurology·Friedhelm HummelLeonardo G Cohen
Jan 30, 2010·Physical Therapy·Julie A WilliamsFelipe Fregni
Feb 16, 2011·The International Journal of Neuropsychopharmacology·Andre Russowsky BrunoniFelipe Fregni
Feb 24, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Charlotte J Stagg, Michael A Nitsche
May 18, 2011·Computational Intelligence and Neuroscience·François TadelRichard M Leahy
Jul 26, 2011·Brain Stimulation·Laura Mordillo-MateosAntonio Oliviero
Feb 22, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S GroppaH R Siebner
Jun 23, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kristina LaaksonenNina Forss
Mar 13, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shin-Yi ChiouYea-Ru Yang
May 30, 2013·Stroke; a Journal of Cerebral Circulation·Cathy StinearWinston Byblow
Jun 4, 2013·NeuroImage·Jacinta O'SheaHeidi Johansen-Berg
Dec 3, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chayanin TangwiriyasakulMichel J A M van Putten
Mar 19, 2014·Neuroscience Letters·Qing Mei WangFelipe Fregni
Mar 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Utako TakechiSadatoshi Tsuji
Sep 10, 2014·Nature Reviews. Neurology·Giovanni Di PinoVincenzo Di Lazzaro
Dec 10, 2014·Brain : a Journal of Neurology·Stéphanie LefebvreYves Vandermeeren
Dec 24, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ulf ZiemannFlorian Müller-Dahlhaus
May 15, 2015·Frontiers in Behavioral Neuroscience·Laura AvanzinoMarco Bove
Jul 22, 2015·Brain Stimulation·Cathy M StinearWinston D Byblow
Aug 22, 2015·Brain Stimulation·Alana B McCambridgeWinston D Byblow
Jul 4, 2016·Brain Stimulation·Marom BiksonAdam J Woods
Jul 5, 2016·Frontiers in Human Neuroscience·Alicia M GoodwillDawson J Kidgell

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

FMA
UE
SPSS
Brainstorm
Neuromag
ARAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.