Neurophysiology and genetics of burning mouth syndrome

European Journal of Pain : EJP
Marina KolkkaSatu K Jääskeläinen

Abstract

Neuropathic mechanisms are involved in burning mouth syndrome (BMS), and variation of the dopamine D2 receptor (DRD2) gene contributes to experimental pain perception. We investigated whether neurophysiologic findings differ in BMS patients compared to healthy controls, and whether 957C>T polymorphism of the DRD2 gene influences thermal sensitivity or pain experience in BMS. Forty-five BMS patients (43 women), mean age 62.5 years, and 32 healthy controls (30 women), mean age 64.8 years, participated. Patients estimated pain intensity, interference, suffering and sleep with Numeric Rating Scale. Blink reflex tests of the supraorbital (SON), mental (MN) and lingual (LN) nerves, and thermal quantitative sensory testing were done. The results were analysed with ANOVA. DRD2 gene 957C>T polymorphism was determined in 31 patients, and its effects on neurophysiologic and clinical variables were analysed. Cool (p = 0.0090) and warm detection thresholds (p = 0.0229) of the tongue were higher in BMS patients than controls. The stimulation threshold for SON BR was higher in patients than in controls (p = 0.0056). The latencies of R2 component were longer in BMS patients than in controls (p = 0.0005) at the SON distribution. Habituation of ...Continue Reading

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Citations

Jun 6, 2020·Journal of Oral Rehabilitation·Víctor Ignacio MadariagaMalin Ernberg
Jun 2, 2020·European Journal of Pain : EJP·Eleonora VecchioMarina de Tommaso
Aug 28, 2021·World Journal of Clinical Cases·Qi-Cui DuWei-Fei Wang
Aug 28, 2021·Biomolecules·Marie Orliaguet, Laurent Misery
Oct 19, 2021·Frontiers in Neuroscience·Janell S Payano SosaDavid A Seminowicz

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