Neurophysiology and neuropharmacology of projections from entorhinal cortex to striatum in the rat

Brain Research
D M FinchO P Kosoyan

Abstract

We studied projections from the entorhinal cortex (Ent) to the striatum in anesthetized rats using extra- and intracellular recording and multibarrel iontophoresis. The majority of recording were from the caudate-putamen (CPu) and core of the nucleus accumbens (AcbC). Electrical stimulation of the Ent evoked synaptic responses in 77% of tests with AcbC neurons and 48% of tests with CPu neurons. In the case of AcbC neurons, 61% of these tests proved to be excitatory and were often followed by inhibitory phases. In contrast to this, only 18% of tests from CPu neurons were excitatory. Intracellular HRP labeling showed that responsive cells were medium spiny neurons. During iontophoretic experiments, application of the glutamatergic AMPA antagonist DNQX could selectively decrease or block excitatory responses. The GABAA antagonist bicuculline methiodide increased cellular firing rates and could reveal excitatory responses, suggesting block of a short-latency, short-duration inhibitory component. Ejection of the GABAB antagonist CGP-35348 could attenuate a later, longer-duration component of inhibition. The results indicate that the Ent excites striatal neurons at least in part by glutamatergic receptors and suggest that this excita...Continue Reading

Citations

Sep 24, 2013·Frontiers in Behavioral Neuroscience·Amy C Reichelt, Jonathan L C Lee
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anni S LeeChristopher Pittenger
Jul 30, 2010·Journal of Cognitive Neuroscience·Talya SadehAnat Maril
Jun 8, 2002·Annual Review of Neuroscience·Mark G Packard, Barbara J Knowlton
Nov 3, 2011·PLoS Computational Biology·Nicholas J Gustafson, Nathaniel D Daw
Apr 11, 2012·The European Journal of Neuroscience·Mónica HilarioRui M Costa
Jun 27, 2014·Frontiers in Systems Neuroscience·Ilana Molochnikov, Dana Cohen
Jul 23, 1999·Annals of the New York Academy of Sciences·P O'DonnellA A Grace
Sep 5, 2008·Neural Plasticity·Cathrin B CantoMenno P Witter

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