Neurophysiology of synaptic functioning in multiple sclerosis

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Mario Stampanoni BassiEnnio Iezzi

Abstract

Multiple sclerosis (MS) is an inflammatory immune-mediate disorder of the central nervous system (CNS), primarily affecting the myelin sheath and followed by neurodegeneration. Synaptic alterations are emerging as critical determinants of early neurodegeneration in MS. Inflammation-induced alterations of synaptic transmission and plasticity have been investigated in vitro and also in human MS using transcranial magnetic stimulation (TMS) techniques. Specific inflammatory cytokines alter glutamatergic and GABAergic transmission, resulting in synaptic hyperexcitability. In both experimental autoimmune encephalomyelitis (EAE) and MS, excitotoxic damage and neurodegeneration are found even in the early phases of disease, conversely inflammation persists in the progressive phases. Inflammatory cytokines also affect synaptic plasticity, as both long-term potentiation (LTP) and long-term depression (LTD) are altered in EAE and in MS patients. In particular, inflammation profoundly subverts plasticity and influence both clinical recovery after a relapse and disease course. Regulation of neuronal activity by cytokines plays important roles in the neuro-immune crosstalk involved in inflammation-associated excitotoxic neuronal damage, and...Continue Reading

Citations

Dec 7, 2017·Frontiers in Molecular Neuroscience·Mario Stampanoni BassiEnnio Iezzi
Jan 13, 2018·Frontiers in Neuroscience·Mario Stampanoni BassiEnnio Iezzi
Jan 5, 2020·Expert Opinion on Therapeutic Targets·Alessandra MusellaGeorgia Mandolesi
Aug 31, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Letizia LeocaniDiego Centonze
Aug 31, 2018·Nature Reviews. Neuroscience·Massimiliano Di FilippoPaolo Calabresi
Aug 24, 2018·Frontiers in Aging Neuroscience·Alessandra MusellaGeorgia Mandolesi
Dec 28, 2019·International Journal of Molecular Sciences·Mario Stampanoni BassiFabio Buttari
Sep 27, 2020·International Journal of Molecular Sciences·Mario Stampanoni BassiEnnio Iezzi
Jun 5, 2018·Neural Plasticity·Francesca Romana RizzoAntonietta Gentile
Feb 15, 2019·Frontiers in Neurology·Mario Stampanoni BassiFabio Buttari
Nov 7, 2019·Journal of Molecular Neuroscience : MN·Luciana Maria FelicianoDaisy Maria Fávero Salvadori
Aug 23, 2019·Neurorehabilitation and Neural Repair·Mario Stampanoni BassiFrancesca Romana Rizzo
Aug 1, 2020·Frontiers in Neurology·Mario Stampanoni BassiEnnio Iezzi
Oct 7, 2020·International Journal of Molecular Sciences·Ettore DolcettiGeorgia Mandolesi
Oct 27, 2020·Expert Opinion on Therapeutic Targets·Tatjana BeutelLucas Schirmer
Sep 22, 2021·Journal of Neurochemistry·Mario Stampanoni BassiAlessandro Usiello

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