Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues

Cancer Management and Research
Mahnaz Seifi-AlanSoudeh Ghafouri-Fard

Abstract

Neuropilin-1 (NRP1) as an isoform-specific receptor for vascular endothelial growth factor and placenta growth factor in endothelial cells has been demonstrated to be expressed in breast cancer cells where it plays functional roles in cell survival, invasion, and migration. We hypothesized that an expression of NRP1 in breast cancer tissues is associated with clinicopathological data of patients and expression of the tumor suppressor miR-206. We evaluated the expression of NRP1 in 48 invasive ductal carcinomas of the breast and their corresponding adjacent noncancerous tissues (ANCTs) by means of real-time polymerase chain reaction. We also extracted data on miR-206 gene expression from the same cohort of patients to evaluate the correlation between expression levels of miR-206 and NRP1. In addition, we quantified NRP1 protein levels using the enzyme-linked immunosorbent assay technique. No significant difference was found in NRP1 expression between tumoral tissues and ANCTs. We also assessed the associations between expression levels of NRP1 and clinicopathological data of patients and found no significant associations between NRP1 transcript levels and any characteristic. However, NRP1 protein concentrations were significantl...Continue Reading

Citations

Jul 10, 2019·Journal of Translational Medicine·Meysam Moghbeli
Jul 14, 2020·International Journal of Radiation Biology·ZhiYuan ChenShunzi Jin
May 31, 2020·Journal of Clinical Laboratory Analysis·Li-Hong HeYong Meng
Mar 29, 2019·Journal of Cellular Biochemistry·Mahnaz Seifi-AlanSoudeh Ghafouri-Fard
Apr 4, 2020·Journal of Molecular Histology·Ho Seok SeoHan Hong Lee
Apr 23, 2021·Journal of Cancer Research and Clinical Oncology·Tilman D RachnerAnn-Kathrin Bittner
Mar 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lansheng ZhangZhengxiang Han

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Datasets Mentioned

BETA
GSE5926
GSE5927

Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GEO2R
R
miRWalk2

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