PMID: 9529250Apr 7, 1998Paper

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

Cell
S SokerM Klagsbrun

Abstract

Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (VEGF165R) is identical to human neuropilin-1, a receptor for the collapsin/semaphorin family that mediates neuronal cell guidance. When coexpressed in cells with KDR, neuropilin-1 enhances the binding of VEGF165 to KDR and VEGF165-mediated chemotaxis. Conversely, inhibition of VEGF165 binding to neuropilin-1 inhibits its binding to KDR and its mitogenic activity for endothelial cells. We propose that neuropilin-1 is a novel VEGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGF-induced angiogenesis.

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Dec 29, 1989·Biochemical and Biophysical Research Communications·E TischerJ A Abraham
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K G PetersL T Williams
Feb 28, 1994·Biochemical and Biophysical Research Communications·V Midy, J Plouët
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R L Kendall, K A Thomas
Jul 2, 1993·Cell·F López-CasillasJ Massagué
Oct 1, 1996·Cytokine & Growth Factor Reviews·M Klagsbrun, P A D'Amore
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Mar 14, 1997·The Journal of Biological Chemistry·Z PoltorakG Neufeld
Aug 22, 1997·Cell·A L KolodkinD D Ginty
Oct 1, 1993·Current Biology : CB·M Klagsbrun, S Soker

❮ Previous
Next ❯

Citations

May 26, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K AaseU Eriksson
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·A LatilR Lidereau
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T J PooleC M Cox
Feb 13, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y S NgP A D'Amore
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·H DingA Guha
Aug 10, 2000·Journal of Neurobiology·F NakamuraS M Strittmatter
Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B L Roman, B M Weinstein
Oct 17, 2002·The Anatomical Record·George E DavisAnil Mavila
Mar 14, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Judith H Harmey, David Bouchier-Hayes
Apr 23, 2002·Journal of Cellular Biochemistry·Pascal N BernatchezMartin G Sirois
Oct 12, 2001·Microscopy Research and Technique·T A Partanen, K Paavonen
Sep 5, 2002·The Journal of Pathology·Tzafra CohenMurray B Resnick
Aug 21, 2007·Molecular Diagnosis & Therapy·Kenta Nakamura, Stanley G Rockson
Feb 9, 2006·Cellular and Molecular Life Sciences : CMLS·S Cébe-SuarezK Ballmer-Hofer
May 25, 2005·Der Urologe. Ausg. A·F Vom DorpA Eisenhardt
Feb 8, 2005·World Journal of Surgery·Changyi ChenQizhi Yao
Jan 15, 2009·Acta Neuropathologica·Heike Beck, Karl H Plate
Dec 13, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Margrit HollbornLeon Kohen
Feb 16, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yasuaki HataTatsuro Ishibashi
Oct 12, 2012·Histochemistry and Cell Biology·Laura OlbrichCarsten Theiss
Jul 31, 2007·Human Genetics·Andrew Lotery, Dorothy Trump
Feb 11, 2012·Cell and Tissue Research·Renee M McFeeAndrea S Cupp
Feb 22, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kimberly Reidy, Alda Tufro
Mar 22, 2006·Journal of Neural Transmission·J V LafuenteB Mitre
Dec 6, 2005·Angiogenesis·Roni MamlukDiane R Bielenberg
Feb 20, 2008·Angiogenesis·Elena GerettiMichael Klagsbrun
Jan 28, 2009·Angiogenesis·Nyall R LondonDean Y Li
Mar 7, 2009·Angiogenesis·Guido SeriniFederico Bussolino
Jan 5, 2008·Biotechnology Letters·Hijiri HasegawaKazunori Ikebukuro
Sep 29, 2006·Cancer Metastasis Reviews·Gera Neufeld, Ofra Kessler
Sep 5, 2007·Cancer Metastasis Reviews·Diane R Bielenberg, Michael Klagsbrun
Feb 28, 2006·Documenta Ophthalmologica. Advances in Ophthalmology·Anne B FultonAmber M Barnaby
Aug 23, 2006·Journal of Mammary Gland Biology and Neoplasia·Arthur M MercurioRobin E Bachelder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.