PMID: 11312112Apr 20, 2001Paper

Neuropilin in the midst of cell migration and retraction

The International Journal of Biochemistry & Cell Biology
S Soker

Abstract

Neuropilin (NRP) is a 140 kDa membrane protein, with a large extracellular domain and a short cytoplasmic tail, that was isolated in 1987 from the optic tactum of Xenopus laevis. About 10 years after its isolation, NRP was identified as a receptor for semaphorin, a family of axonal chemorepellent proteins and for vascular endothelial growth factor (VEGF), a family of potent angiogenic factors. In the nervous system, NRP forms a high affinity semaphorin-binding complex with a receptor tyrosine kinase, plexin, that mediates semaphorin-induced growth cone collapse. On the endothelium, NRP is expressed together with KDR, a VEGF receptor tyrosine kinase. We have shown that NRP potentiated KDR-mediated endothelial cell migration and proliferation. Some tumor cells can express high levels of NRP, which is typically their only VEGF receptor, but do not seem to respond to VEGF directly. Possible use of NRP as a target for VEGF antagonists, in the context of antiangiogenic therapy, are described.

References

Sep 1, 1996·Scientific American·J Folkman
Aug 22, 1997·Cell·A L KolodkinD D Ginty
Nov 13, 1998·Current Opinion in Neurobiology·H Fujisawa, T Kitsukawa
Apr 15, 1999·Annual Review of Neuroscience·B K Mueller
Oct 16, 1999·Cell·T TakahashiS M Strittmatter

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Citations

Oct 19, 2002·Molecular Aspects of Medicine·Masashi NomiShay Soker
Apr 24, 2004·The American Journal of Surgical Pathology·Donna E HanselAnirban Maitra
Nov 6, 2004·Reviews in the Neurosciences·Takao YasuharaIsao Date
Jan 1, 2009·OncoTargets and Therapy·Ajithkumar PuthillathMarwan G Fakih
Feb 11, 2003·Journal of Cellular Biochemistry·Mireille RossignolMichael Klagsbrun
Apr 28, 2006·Journal of Neurochemistry·Elisabet HermansonThomas Perlmann
Jun 19, 2004·Genomics·Frank C CackowskiShi-Yuan Cheng
Sep 11, 2002·Developmental Biology·Damien BatesDonald F Newgreen
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Feb 22, 2003·Cell and Tissue Research·Georg WieczorekUlrike A Nuber
Oct 12, 2004·Hematology/oncology Clinics of North America·Alexander A Parikh, Lee M Ellis
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A Méjean, T Lebret

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