Neuroplasticity and brain repair after stroke

Current Opinion in Neurology
S C Cramer, Jeff D Riley

Abstract

This review considers recent insights into the neurobiology of repair after stroke in animals and humans, the range of emerging therapies to promote repair and recovery after the acute phase of stroke, and issues related to optimizing trials of such therapies. Animal studies continue to shed light on the molecular, vascular, glial, neuronal, behavioral, and environmental events that are important to the spontaneous behavioral recovery that is observed during the weeks after a stroke. Animal and human studies are examining a wide range of potential interventions that may favorably modify outcome, including small molecules, growth factors, cell-based approaches, electromagnetic stimulation, a range of devices and robots, and intense physiotherapy methods, including constraint-induced movement therapy. Optimal prescription of these restorative therapies in human patients with stroke requires further study, including defining potential roles for functional neuroimaging. A wide range of therapies shows promise for improving poststroke brain repair. Insights into the neurobiology of brain repair after stroke in animals and in humans continue to accrue. This information might prove useful in designing and implementing clinical trials ...Continue Reading

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Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

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