Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kristina A FenoglioTallie Z Baram

Abstract

An eloquent example of experience-induced neuroplasticity involves the enduring effects of daily "handling" of rat pups on the expression of genes regulating hormonal and behavioral responses to stress. Handling-evoked augmentation of maternal care of pups induces long-lasting reduction of hypothalamic corticotropin releasing hormone (CRH) expression and upregulates hippocampal glucocorticoid receptor levels. These changes promote a lifelong attenuation of hormonal stress responses. We have found previously that handling-evoked downregulation of CRH expression occurs already by postnatal day 9, implicating it as an early step in this experience-induced neuroplasticity. Here, we investigated the neuronal pathways and cellular mechanisms involved. CRH mRNA expression in hypothalamic paraventricular nucleus (PVN) diminished after daily handling but not after handling once only, indicating that "recurrent" handling was required for this effect. Return of handled pups to their cage provoked a burst of nurturing behavior in dams that, in turn, induced transient, coordinate Fos expression in selected regions of the pups' brains. These included central nucleus of the amygdala (ACe) and bed nucleus of the stria terminals (BnST), regions...Continue Reading

References

Apr 24, 1997·Annals of the New York Academy of Sciences·T Z BaramL Schultz
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CaldjiM J Meaney
Jun 17, 1998·Endocrine Reviews·E R De KloetM Joëls
Feb 22, 2000·Annals of the New York Academy of Sciences·D D FrancisM J Meaney
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T DubéT Z Baram
Aug 13, 2002·Stress : the International Journal on the Biology of Stress·M MartinezJ Herbert
Sep 11, 2002·Trends in Neurosciences·Sarit Avishai-ElinerTallie Z Baram
Dec 4, 2002·Nature Reviews. Neuroscience·Anne E WestMichael E Greenberg
Jul 12, 2003·Brain Research. Developmental Brain Research·Mario CabaRae Silver
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuncai ChenTallie Z Baram
Nov 9, 2004·The Journal of Endocrinology·Alistair I FreemanKaren E Chapman

❮ Previous
Next ❯

Citations

Jul 3, 2009·European Archives of Psychiatry and Clinical Neuroscience·Miriam Schneider
Mar 10, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L A Velloso, M W Schwartz
Oct 4, 2007·Epilepsia·Roland A Bender, Tallie Z Baram
Jun 21, 2008·Endocrinology·Courtney J RiceTallie Z Baram
Mar 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuncai ChenTallie Z Baram
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aniko KorosiTallie Z Baram
Oct 23, 2013·Frontiers in Neuroendocrinology·Limor Regev, Tallie Z Baram
Nov 19, 2014·Nature Communications·Katharina GappIsabelle M Mansuy
Dec 20, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Badowska-Szalewska EwaMoryś Janusz
Apr 2, 2011·Physiology & Behavior·Jaidee K ZavalaKristin L Gosselink
Nov 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stephen C Heinrichs
Jun 9, 2009·Brain Research·Cassandra KazlSookyong Koh
Feb 16, 2008·European Journal of Pharmacology·Aniko Korosi, Tallie Z Baram
Aug 19, 2007·Brain Research·Elisa C Winkelmann-DuarteAldo B Lucion
Jan 12, 2007·Epilepsy Research·Alyssa Richman, Stephen C Heinrichs
Sep 24, 2010·Developmental Psychobiology·Aniko Korosi, Tallie Z Baram
Sep 10, 2014·Developmental Cell·Isabella GarciaBenjamin R Arenkiel
Jun 19, 2013·Stress : the International Journal on the Biology of Stress·Jessica L CopeTallie Z Baram
Nov 4, 2008·Brain Research·Tatiane S C CamozzatoAldo B Lucion
Jun 15, 2014·Frontiers in Neuroendocrinology·Benjamin G GunnDelia Belelli
Apr 9, 2014·Frontiers in Endocrinology·Millie Rincón-Cortés, Regina M Sullivan
Mar 22, 2014·Frontiers in Behavioral Neuroscience·David T HsuSeema Bhatnagar
Apr 30, 2013·Behavioral Sciences·Reto Bisaz, Regina M Sullivan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.