Abstract
To assess the effects of acetylsalicylic acid (ASA) on glutamate and interleukin-6 (IL-6) release in the striatum of rats suffering from cerebral ischemia, we used the microdialysis technique with probes implanted 2 h prior to stroke onset. A total of 36 rats were randomly assigned to either temporary (90 min, n=18) or permanent (n=18) middle cerebral artery occlusion (MCAO). Animals received either a bolus of 40 mg/kg ASA or saline as control 30 min after stroke onset. Permanent MCAO led to large infarct volumes with no differences between treatment with ASA (239.8+/-4.1 mm3) and saline (230.1+/-3.9 mm3, p=0.15). In contrast, ASA therapy in temporary ischemia (87.2+/-6.2 mm3) reduced infarct size significantly compared to placebo (155.6+/-4.8 mm3, p<0.0001). Only in temporary ischemia, ASA application reduced glutamate significantly at the time points 90, 120, and 150 min after MCAO. Pooled post-ischemic microdialysate concentrations of IL-6 in temporary MCAO were significantly higher after ASA treatment (215+/-81 pg/mL, p=0.0297) than in saline-treated rats (80+/-13 pg/mL). In the permanent MCAO group, no difference in IL-6 between the ASA (125+/-21 pg/mL) and saline group (68+/-34 pg/mL) was noted. No differences were seen f...Continue Reading
References
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·G Y YangP R Weinstein
Feb 1, 1990·Inflammation·S B AbramsonG Weissmann
Aug 1, 1990·Biochemical Pharmacology·S Umeki
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 1, 1987·Neurosurgery·B T AndrewsB Pereira
Apr 1, 1982·Agents and Actions·G PekoeD English
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·C KaltschmidtP A Baeuerle
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·A SlivkaL Horrocks
Apr 1, 1994·Journal of the Neurological Sciences·K FassbenderM Hennerici
Aug 12, 1994·Science·E Kopp, S Ghosh
Nov 22, 1996·Science·M GrilliP Spano
Oct 28, 1997·Stroke; a Journal of Cerebral Circulation·M W RiepeA Raupach
Feb 5, 1999·Stroke; a Journal of Cerebral Circulation·W R SchäbitzM Fisher
Apr 15, 1999·Neuroreport·N KhayyamW M Burnham
May 7, 1999·Stroke; a Journal of Cerebral Circulation·J VogelW Kuschinsky
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SuzukiY Fukuuchi
Apr 13, 2000·Neuropharmacology·M A MoroP Lorenzo
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Javier De CristóbalM A Moro
Apr 8, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Oliver HerrmannMarkus Schwaninger
Jan 31, 2004·Brain Research·Christian BergerArmin Grau
Jul 7, 2005·Journal of Neurochemistry·Toru YamashitaHideyuki Okano
Citations
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jens Minnerup, Wolf-Rüdiger Schäbitz
Sep 28, 2013·PloS One·Bing Chun YanMoo-Ho Won
Mar 26, 2014·Journal of Neuroinflammation·Zhongxing WangZhiyi Zuo
Feb 27, 2014·Cellular and Molecular Neurobiology·Zhi HeYing Qian
Jan 6, 2011·Neurochemical Research·Alexander ZlotnikVivian I Teichberg
Sep 25, 2012·Neurotoxicology·Marcio de Araujo FurtadoDebra Yourick
Nov 1, 2011·Brain Stimulation·Zhenghui SunJoel H Greenberg
Dec 25, 2008·European Journal of Pharmacology·Zhi HeLianjun Guo
Aug 2, 2015·Brain, Behavior, and Immunity·Dan HanYunman Li
Oct 5, 2011·Journal of Neuroscience Research·Wei WangYi-Na Huang
Sep 17, 2014·Free Radical Biology & Medicine·Preeti DohareAlexander A Mongin
May 25, 2010·Experimental Neurology·Alexander ZlotnikVivian I Teichberg
Jul 23, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sarah NelsonNatalia S Rost
Jan 27, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Francisco CamposJosé Castillo
Jul 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter KraftChristoph Kleinschnitz
Oct 8, 2011·Journal of Neurosurgical Anesthesiology·Alexander ZlotnikVivian I Teichberg
Sep 9, 2011·Der Nervenarzt·P KraftC Kleinschnitz
Jun 26, 2020·Genes·Ivan B FilippenkovLyudmila V Dergunova
Nov 13, 2012·Anesthesiology·Siyuan P ShengDavid S Warner
Jul 27, 2018·Inflammation·Mohammad-Reza RahmaniMohammad Allahtavakoli
Sep 7, 2018·BMC Genomics·Lyudmila V DergunovaSvetlana A Limborska
Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Maciej BladowskiAdrian Doroszko
May 7, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Liang ZhangWenbao Li
Mar 3, 2018·Life Sciences·Mohammad-Reza RahmaniMohammad Allahtavakoli
Jun 29, 2021·ACS Chemical Neuroscience·Feng LiWenbao Li
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad-Reza RahmaniMohammad Allahtavakoli