Abstract
Oxymatrine, extracted from a traditional Chinese herb, Sophora flavescens Ait, has shown a variety of pharmacological actions. Recently, we have proved that oxymatrine protected brain from ischemic damage. However, little is known about the exact mechanisms of this effect. This study is to investigate the potential neuroprotection of oxymatrine and explore the underlying mechanisms. Male Sprague-Dawley rats were subjected to acute permanent middle cerebral artery occlusion (MCAO). Oxymatrine was administered immediately after cerebral ischemia. At 24 hours after MCAO, brain water content and infarct volume were measured. The expression of 12/15-lipoxygenase (12/15-LOX), p38 mitogen-activated protein kinase (p38 MAPK), phosphorylated p38 MAPK (phospho-p38 MAPK), and cytosolic phospholipase A2 (cPLA2) was measured by immunohistochemistry, western blot and reverse transcription-polymerase chain reaction (RT-PCR). Compared with MCAO group, oxymatrine dramatically reduced brain water content (P<0.05) and infarct volume (P<0.05). Consistent with these indices, the overexpressions of 12/15-LOX, phospho-p38 MAPK, and cPLA2 were significantly decreased in oxymatrine group. But the expression of p38 MAPK was not affected at the mRNA leve...Continue Reading
References
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jul 1, 1983·Journal of Neurosurgery·H Koga, G Austin
Apr 1, 1994·Journal of the Neurological Sciences·K FassbenderM Hennerici
Mar 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M K BaskayaR J Dempsey
Dec 24, 1997·Nature·J V BonventreA Sapirstein
Jan 22, 2002·Journal of Ethnopharmacology·Shuang-Cheng MaSong Fong Lee
Jul 18, 2003·Journal of Neuroscience Research·Rao Muralikrishna Adibhatla, James F Hatcher
Mar 15, 2005·Journal of Ethnopharmacology·G L XuS Q Yu
Oct 14, 2005·World Journal of Surgery·Hongchi JiangXueying Sun
Jan 31, 2006·Free Radical Biology & Medicine·Rao Muralikrishna Adibhatla, J F Hatcher
Oct 21, 2006·Stroke; a Journal of Cerebral Circulation·Klaus van LeyenEng H Lo
Aug 30, 2007·Phytotherapy Research : PTR·Ye SunKwok Pui Fung
Sep 11, 2007·Experimental Brain Research·Petter VikmanLars Edvinsson
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Sep 30, 2008·Surgery Today·Jinpeng ZhaoXueying Sun
Mar 17, 2009·Brain Research·Ying LiuHong-Guang Fan
May 19, 2009·Brain Research·Chenhui YangYing Liu
Nov 19, 2009·Journal of Translational Medicine·Shaheen E LakhanMagdalena Hofer
Feb 20, 2010·Brain Research·Lili CuiWei Du
Feb 26, 2010·Mediators of Inflammation·Hongguang FanJing Yin
Citations
Dec 31, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiao-Qiao DongMan Huang
Apr 4, 2013·BMC Neuroscience·Jakob O StrömElvar Theodorsson
Jul 12, 2011·Chinese Medicine·Shan-Yu Su, Ching-Liang Hsieh
Jun 13, 2014·Neurochemical Research·Ting ZhaoLili Cui
Apr 17, 2012·Brain Research·Min XuHui-Ling Zhang
Jun 30, 2015·Neurochemistry International·Peng ZhaoJian-Qiang Yu
Jul 4, 2012·Journal of Ethnopharmacology·Man HuangZu-Yong Zhang
Apr 24, 2012·Brain Research Bulletin·Zongjie LiuLinyu Chen
Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kun ZhangMing-gao Zhao
Mar 4, 2017·Neurological Research·Zhe ZhangLei Cao
Jun 25, 2015·Acta Cirúrgica Brasileira·Guanjun JiangTao Qiu
Jan 28, 2017·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Liping WangXuesong Tian
Jul 23, 2018·Metabolic Brain Disease·Xu-Hua GeGuo-Ji Zhu
Nov 25, 2016·Biomedical Reports·Feijia DingYin Wang
Jun 13, 2020·Frontiers in Pharmacology·Ping GanXiaojuan Qian
Nov 17, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xu LanFengqin Xu
Jan 21, 2021·International Journal of Molecular Sciences·Hadi MohsenpourMohammad Hosein Farzaei
May 1, 2021·Frontiers in Pharmacology·Wei WeiJian-Qiang Yu
May 19, 2021·Ultrastructural Pathology·Amany Mohamed ShalabyMona Tayssir Sadek
May 20, 2021·Oxidative Medicine and Cellular Longevity·Hui XuMingfu Wang