Neuroprotection by hypothermia plus alkalinization of dorsal root ganglia neurons through ischemia

Annals of the New York Academy of Sciences
D P Kuffler

Abstract

Brain and spinal cord (CNS) trauma typically directly kill some neurons leading to permanent neurological deficits. However, they also lead to a number of triggers which in turn frequently kill a vastly larger number of neurons than were killed by the initial insult. The best mechanism for reducing the extent of neurological deficits is to minimize the number of neurons that die immediately due to the trauma, and post-trauma sequelae. Neuroprotection techniques have taken many diverse forms with a breadth too great for a short review. Therefore, this review is focused on the roles of only a small number of neuroprotective agents, with its primary focus being on neuroprotection provided by hypothermia, alone and when combined with the other methods. Included are also recent results involving a novel neuroprotective technique, tested on adult human dorsal root ganglion neurons, comparing the influences of hypothermia and alkalinization singly, providing fourfold and eightfold increases in neuroprotection, respectively, but when combined providing a 26-fold increase in neuroprotection. This combinatorial approach to neuroprotection holds great promise for enhancing the degree of neuroprotection clinically following CNS trauma, lea...Continue Reading

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Citations

May 2, 2012·Therapeutics and Clinical Risk Management·Damien P Kuffler
Aug 30, 2014·Journal of Neurosurgery. Spine·Faiz U Ahmad, Allan D Levi
Jul 28, 2015·International Journal of Molecular Sciences·Jiaqiong Wang, Damien D Pearse
May 26, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Paul McCarthyAlireza Minagar
May 17, 2014·The International Journal of Neuroscience·Mark M Stecker, Matthew Stevenson
Feb 7, 2018·Journal of American College Health : J of ACH·Emily F RothmanVictoria Banyard
Jun 28, 2019·Frontiers in Neuroscience·Ying-Jian SunGuang-Yu Li

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