Neuroprotection by noble gases: New developments and insights

Der Anaesthesist
Astrid V FahlenkampMark Coburn

Abstract

Noble gases are chemically inert elements, some of which exert biological activity. Experimental neuroprotection in particular has been widely shown for xenon, argon and helium. The underlying mechanisms of action are not yet fully understood. Besides an interference with neuronal ion-gated channels and cellular signaling pathways as well as anti-apoptotic effects, the modulation of neuroinflammation seems to play a crucial role. This review presents the current knowledge on neuroprotection by noble gases with a focus on interactions with the neuronal-glial network and neuroinflammation and the perspectives on clinical applications.

References

Dec 9, 1998·Nature·N P FranksW R Lieb
Feb 25, 2003·Life Sciences·Christian PetzeltWolfgang J Kox
Feb 8, 2005·British Journal of Anaesthesia·A DinseH U Weigt
Jul 22, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daqing MaMervyn Maze
Jul 29, 2005·Annals of Neurology·Daqing MaMervyn Maze
Dec 24, 2005·Stroke; a Journal of Cerebral Circulation·John DingleyMarianne Thoresen
May 1, 2007·Experimental Neurology·Yi PanW Michael Panneton
Jan 25, 2008·Critical Care Medicine·Mark CoburnNicholas P Franks
Jun 24, 2008·Neuroscience Letters·Davide CattanoFrancesco Giunta
Apr 23, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hélène N DavidJacques H Abraini
Dec 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Philip D LoetscherMark Coburn
Jul 27, 2010·Annals of Neurology·Elavazhagan ChakkarapaniMarianne Thoresen
Aug 4, 2010·Journal of Molecular Neuroscience : MN·Astrid V FahlenkampCordian Beyer
May 5, 2011·Neuroscience Letters·Yi PanW Michael Panneton
Nov 19, 2011·European Journal of Pharmacology·Astrid V FahlenkampMark Coburn
May 25, 2012·Acta Anaesthesiologica Scandinavica·Y W YangW P Cheng
Jun 26, 2012·Brain, Behavior, and Immunity·Alok Kumar, David J Loane
Sep 20, 2012·Nature Immunology·Peter J Murray, Stephen T Smale
Mar 28, 2013·Frontiers in Neurology·Diana G Hernandez-OntiverosCesar V Borlongan
Apr 18, 2013·Anesthesiology·Hemmen SabirMarianne Thoresen
Oct 14, 2014·International Journal of Molecular Sciences·Anke HölligUNKNOWN Argon Organo-Protective Network (AON)

❮ Previous
Next ❯

Citations

Sep 25, 2015·Der Anaesthesist·V-S Eckle, S N Stehr
Feb 21, 2016·Pharmacology & Therapeutics·David A WinklerIra Katz
May 18, 2016·Critical Care Medicine·Anke HölligMark Coburn
Feb 26, 2020·Intensive Care Medicine Experimental·Roehl AnnaCoburn Mark
Aug 6, 2020·International Journal of Molecular Sciences·Sophia M SchmitzTom F Ulmer
Jun 23, 2021·Seminars in Fetal & Neonatal Medicine·Aravanan A ChakkarapaniUNKNOWN Newborn Brain Society Guidelines and Publications Committee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.