Neuroprotection by pharmacologic blockade of the GAPDH death cascade

Proceedings of the National Academy of Sciences of the United States of America
Makoto R HaraSolomon H Snyder

Abstract

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) participates in a cell death cascade wherein a variety of stimuli activate nitric oxide (NO) synthases with NO nitrosylating GAPDH, conferring on it the ability to bind to Siah, an E3-ubiquitin-ligase, whose nuclear localization signal enables the GAPDH/Siah protein complex to translocate to the nucleus where degradation of Siah targets elicits cell death. R-(-)-Deprenyl (deprenyl) ameliorates the progression of disability in early Parkinson's disease and also has neuroprotective actions. We show that deprenyl and a related agent, TCH346, in subnanomolar concentrations, prevent S-nitrosylation of GAPDH, the binding of GAPDH to Siah, and nuclear translocation of GAPDH. In mice treated with the dopamine neuronal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), low doses of deprenyl prevent binding of GAPDH and Siah1 in the dopamine-enriched corpus striatum.

References

Feb 1, 1992·Journal of Neuroscience Research·P T Salo, W G Tatton
Dec 1, 1991·Journal of Neuroscience Research·W G Tatton, C E Greenwood
May 24, 1990·The New England Journal of Medicine
Aug 2, 1990·European Journal of Pharmacology·K T FinneganJ W Langston
Nov 16, 1989·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·S KnollemaG J ter Horst
Jan 21, 1993·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
Jun 10, 1993·The New England Journal of Medicine·O S Kofman
Jun 10, 1993·The New England Journal of Medicine·J Mermin, R Granich
Dec 1, 1996·Neurology·W Ondo, J Jankovic
Dec 1, 1996·Neurology·H W Sander, H Bartfeld
Mar 1, 1997·Neuroscience and Biobehavioral Reviews·I A PatersonC Voll
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·A SawaS H Snyder
Feb 2, 2000·Biochemistry·J P EuJ S Stamler
Feb 15, 2001·Nature Cell Biology·S R JaffreyS H Snyder
Oct 3, 2002·Journal of Neurochemistry·Allen S MandirTed M Dawson
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·De-Maw ChuangVladimir V Senatorov
Apr 27, 2005·Brain Research. Brain Research Reviews·Silvia MandelMoussa B H Youdim

❮ Previous
Next ❯

Citations

Feb 5, 2010·Apoptosis : an International Journal on Programmed Cell Death·Kenny K K Chung
Apr 25, 2006·Cellular and Molecular Neurobiology·Makoto R Hara, Solomon H Snyder
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Weihai Ying
Jun 8, 2010·ACS Chemical Biology·Vaishali SinhaGregory R J Thatcher
Jun 17, 2008·Nature Cell Biology·Nilkantha SenAkira Sawa
Sep 21, 2007·Nature Reviews. Neuroscience·Vittorio CalabreseAnna Maria Giuffrida Stella
Mar 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anthony H K TsangKenny K K Chung
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ritu ChakravartiDennis J Stuehr
Aug 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Craig NichollsJun-Ping Liu
Oct 20, 2009·The Journal of Biological Chemistry·Hidemitsu NakajimaTadayoshi Takeuchi
Mar 30, 2012·The Journal of Biological Chemistry·Ritu Chakravarti, Dennis J Stuehr
Oct 13, 2006·Antioxidants & Redox Signaling·Joseph SteinerAvindra Nath
Aug 22, 2008·Antioxidants & Redox Signaling·Andrew B Knott, Ella Bossy-Wetzel
Dec 3, 2009·Antioxidants & Redox Signaling·Sergio Rosales-CorralGabriela Lopez-Armas
Jun 30, 2009·Antioxidants & Redox Signaling·Vittorio CalabreseD Allan Butterfield
Sep 4, 2010·Antioxidants & Redox Signaling·Neelam Shahani, Akira Sawa
Jun 5, 2012·Antioxidants & Redox Signaling·Tomohiro Nakamura, Stuart A Lipton
May 19, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Miguel A Ortiz-OrtizJosé M Fuentes
May 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ava E Schlisser, Barbara F Hales
Oct 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anton PekcecKlaus van Leyen
Aug 2, 2006·Annual Review of Pharmacology and Toxicology·Makoto R Hara, Solomon H Snyder
Jan 1, 2013·Proteome Science·Akira T KomatsubaraKentaro Ozawa
Mar 23, 2010·PloS One·Luke H BradleyGreg A Gerhardt
Sep 24, 2014·Pathologie-biologie·N El KadmiriA Soukri
May 4, 2007·Medical Hypotheses·Elijah W StommelBrent T Harris
Mar 13, 2014·Current Opinion in Psychiatry·Francesco E EmilianiAkira Sawa
Feb 20, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rona R Ramsay
Jan 10, 2016·Free Radical Biology & Medicine·Vladimir F LazarevBoris A Margulis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.