PMID: 26831257Feb 3, 2016Paper

Neuroprotection by Vitamin C Against Ethanol-Induced Neuroinflammation Associated Neurodegeneration in the Developing Rat Brain

CNS & Neurological Disorders Drug Targets
Ashfaq AhmadMyeong Ok Kim

Abstract

Ethanol induces oxidative stress and its exposure during early developmental age causes neuronal cell death which leads to several neurological disorders. We previously reported that vitamin C can protect against ethanol-induced apoptotic cell death in the developing rat brain. Here, we extended our study to understand the therapeutic efficacy of vitamin C against ethanol-induced oxidative stress, neuroinflammation mediated neurodegeneration in postnatal day 7 (PND7) rat. A single episode of ethanol (5g/kg) subcutaneous administration to postnatal day 7 rat significantly induced the production of reactive oxygen species (ROS), and activated both microglia and astrocytes followed by the induction of different apoptotic markers. On the other hand, due to its free radical scavenging properties, vitamin C treatment significantly reduced the production of reactive oxygen species, suppressed both activated microglia and astrocytes and reversed other changes including elevated level of Bax/Bcl-2 ratio, cytochrome c and different caspases such as caspase-9 and caspase-3 induced by ethanol in developing rat brain. Moreover, vitamin C treatment also reduced ethanol-induced activation of Poly [ADP-Ribose] Polymerase 1(PARP-1) and neurodeg...Continue Reading

Citations

Aug 4, 2018·Current Medical Science·Qian-Qian HanJian-Guo Chen
May 15, 2019·International Journal of Molecular Sciences·Stephanie AndradeMaria do Carmo Pereira
Feb 13, 2020·Journal of Clinical Medicine·Clarissa CataleValeria Carola
Jan 25, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Michael J Lewis
Jun 18, 2017·Pharmacological Reports : PR·Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
Jun 28, 2017·Nutrients·Fiammetta MonacelliAlessio Nencioni
Sep 14, 2018·Frontiers in Molecular Neuroscience·Md JakariaDong-Kug Choi
May 31, 2021·Neurochemistry International·Charles Elias AssmannIvana Beatrice Mânica da Cruz
Jul 13, 2021·Frontiers in Aging Neuroscience·Tahir AliMyeong Ok Kim
Aug 17, 2021·Journal of Alzheimer's Disease : JAD·Luciana Domett SiqueiraSergio T Ferreira
Jul 19, 2017·ACS Chemical Neuroscience·Abhijeet SinghBjorn John Stephen

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