Neuroprotection in brain and spinal cord trauma

Current Opinion in Anaesthesiology
Eugene S Fu, Ramachandra P Tummala

Abstract

Traumatic brain and spinal cord injuries continue to be a public health problem. These types of injuries often occur in early adulthood and have a major impact for society. This review discusses strategies and therapeutic agents for perioperative neuroprotection in the management of brain and spinal cord trauma. There are no definitive drugs or strategies that can be utilized to provide perioperative neuroprotection in brain and spinal cord trauma patients. Phase III trials of several pharmacologic agents, including inhibitors of oxidative and excitotoxic injury, have been unable to demonstrate clinical efficacy. Although experimental animal data for hypothermia have been promising over the years, clinical application of therapeutic hypothermia cannot be recommended for routine use in neurotrauma patients. Administration of methylprednisolone, which has become common practice in acute spinal cord injury, has come under close scrutiny. Various experimental animal investigations suggest that potential therapeutic agents include estrogen, progesterone, minocycline, erythropoietin, and magnesium. The main priority in the initial treatment of brain and spinal cord trauma is to maintain oxygenation and perfusion in order to avoid agg...Continue Reading

References

Aug 3, 2000·Frontiers in Bioscience : a Journal and Virtual Library·R Vink, I Cernak
Nov 7, 2000·Journal of Neuroimmunology·P D Drew, J A Chavis
Feb 24, 2001·The New England Journal of Medicine·G L CliftonM Schwartz
Jul 4, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C WiessnerM Gassmann
Nov 28, 2001·Current Opinion in Neurology·D Short
Jun 4, 2002·Nature Reviews. Neuroscience·Christian Behl
Aug 9, 2002·Anesthesiology Clinics of North America·Verna L Baughman
Aug 9, 2002·Anesthesiology Clinics of North America·Eric Bedell, Donald S Prough
Nov 15, 2002·Neurosurgery·M N HadleyT C Ryken
Mar 15, 2003·Internal Medicine·Ryuzo Sasaki
Apr 11, 2003·Journal of the Neurological Sciences·Joji InamasuKiyoshi Ichikizaki
May 24, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Erkan KaptanogluYamac Taskin
Jun 12, 2003·JAMA : the Journal of the American Medical Association·Lauralyn A McIntyreJames S Hutchison
Jun 14, 2003·Brain : a Journal of Neurology·Jennifer E A WellsV Wee Yong
Jun 27, 2003·Journal of Neurosurgical Anesthesiology·Robert D StevensMarek A Mirski
Jul 18, 2003·Journal of Neurotrauma·Eiichi SuehiroJohn T Povlishock
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xin WangRobert M Friedlander
Sep 27, 2003·Epilepsia·John Bruns, W Allen Hauser
Dec 17, 2003·Journal of Neurosurgical Anesthesiology·Harald G Fritz, Reinhard Bauer
Feb 11, 2004·Experimental Neurology·Takamoto SuzukiW Dalton Dietrich
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yang D TengRobert M Friedlander
Feb 28, 2004·Journal of Neurotrauma·Hülya BayirPatrick M Kochanek
Apr 9, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Giovanni GrassoMichael Brines

❮ Previous
Next ❯

Citations

Jun 5, 2010·Medical & Biological Engineering & Computing·Katisha D Smith, Liang Zhu
Jul 7, 2012·AJNR. American Journal of Neuroradiology·P D PurdyM S Riegel
Dec 11, 2013·Translational Stroke Research·Shoji YokoboriM Ross Bullock
Sep 19, 2007·Expert Opinion on Emerging Drugs·Paul A Lapchak, Dalia M Araujo
Feb 9, 2013·Archives of Physical Medicine and Rehabilitation·Yue CaoJames S Krause
May 5, 2009·Experimental Neurology·Vassilios Papadopoulos, Laurent Lecanu
Feb 12, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shyam GajavelliM Ross Bullock
May 29, 2013·CNS Neuroscience & Therapeutics·Shoji YokoboriRoss Bullock
Sep 19, 2012·Journal of Neurosurgery. Spine·Charles H TatorRobert G Grossman
Nov 2, 2014·Journal of Bioenergetics and Biomembranes·Shyam GajavelliRoss M Bullock
Apr 29, 2016·Journal of Intensive Care·Shoji Yokobori, Hiroyuki Yokota
Aug 23, 2019·Clinics·Alderico Girão Campos de BarrosTarcísio Eloy Pessoa de Barros-Filho
Aug 10, 2019·Neural Regeneration Research·Paul A LapchakAli Khoynezhad

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Bogdan StoicaAlan I Faden
Current Opinion in Neurology
Kevin K W WangRonald L Hayes
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Robert Vink, Alan J Nimmo
© 2021 Meta ULC. All rights reserved