Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains

Journal of Neuroimmunology
Gil M LewitusM Schwartz

Abstract

The ability to cope with ongoing neurodegeneration after injury to the central nervous system of mammals differs among strains and depends in part on the animal's ability to manifest a T-cell-mediated protective response. After CNS injury, strain-related differences were observed. Moreover, the post-injury effect of naturally occurring regulatory CD4+CD25+ T cells was found to differ in different strains. In this study, using partially injured optic nerves of Balb/c/OLA and C57BL/6J mice as models, we observed strain-related differences in the T-cell-mediated protection obtained by antigens administered via the nasal route. Active immunization with myelin-related antigens emulsified in complete Freund's adjuvant had a beneficial effect on both strains, whereas mucosal administration of the same antigens was destructive in mice of the Balb/c/OLA strain but protective in C57BL/6J mice.

References

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Citations

Jun 20, 2008·Brain, Behavior, and Immunity·Gil M LewitusMichal Schwartz
Sep 25, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·P A McCombe, S J Read
Apr 30, 2013·Neurological Research·William A LiYuchuan Ding
Jun 6, 2012·Nature Reviews. Neurology·Ángel ChamorroRoland Veltkamp
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresa LambeRichard J Cornall

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