Neuroprotection of VEGF-expression neural stem cells in neonatal cerebral palsy rats

Behavioural Brain Research
Xiang-Rong ZhengLe Zhong

Abstract

Cerebral palsy (CP) is a very common neural system development disorder that can cause physical disability in human. Here, we studied the neuroprotective effect of vascular endothelial growth factor (VEGF)-transfected neural stem cells (NSCs) in newborn rats with cerebral palsy (CP). Seven-day-old Sprague-Dawley rats were randomly divided into four groups: sham operation (control group), PBS transplantation (PBS group), VEGF+NSCs transplantation (transgene NSCs group) and NSCs transplantation groups (NSCs group). PBS, Transgene NSCs and NSCs groups respectively received stereotactic injections of PBS, lentiviral vector (pGC-FU-VEGF) infected NSCs or a NSCs suspension in the left sensory-motor cortex 3 days after CP model was established. The NSCs activity, their impacts on neural cell growth and apoptosis, brain development and animal behaviors were examined on the animals up to age 35-days. As expected, unilateral carotid artery occlusion plus hypoxia (cerebral palsy model) resulted in severe neural developmental disorders, including slowed growth, increased in cortical neuron apoptosis, decreased cerebral cortex micro-vessel density and retarded behavior developments. Transplantation of NSCs not only resulted in increases in ...Continue Reading

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Citations

Jun 27, 2015·Progress in Retinal and Eye Research·Elena VecinoSansar C Sharma
Jun 19, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Feifei WangYusuke Sagara
Jul 4, 2012·Neuroscience Letters·Aliz SzaboKrisztina Kovacs
Oct 3, 2018·British Journal of Pharmacology·Khaled ElmasryMohamed Al-Shabrawey
Oct 13, 2017·Cell Death & Disease·Yuewen TangLin Cheng
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár
Dec 16, 2020·Neural Regeneration Research·Zhong-Yue LvJing Liu
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Bo DouXixi Yin
Sep 21, 2021·Stem Cells Translational Medicine·Madeleine J SmithCourtney A McDonald

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