Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage

European Journal of Pharmacology
Yi-Ruu LinMing-Huan Chan

Abstract

The aim of the present study was to investigate the neuroprotective effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, against neuron toxicity induced by glucose deprivation, excitatory amino acids and hydrogen peroxide (H(2)O(2)) in cultured rat cerebellar granule cells. Cell membrane damage was measured with a lactate dehydrogenase (LDH) release assay and 3-(4,5-dimethyl-2 thiazoyl)-2,5-diphenyl-tetrazolium bromide (MTT) assay was used to assess mitochondrial activity, reflecting cell survival. Results showed that honokiol and magnolol alone did not affect mitochondrial function and cell damage, but significantly reversed glucose deprivation-induced mitochondrial dysfunction and cell damage. The glutamate receptor blocker MK-801 and antioxidant vitamin E also provided protection against this damage. Furthermore, honokiol was more potent than magnolol in protecting against glutamate-, N-methyl-D-aspartate (NMDA)- and H(2)O(2)-induced mitochondrial dysfunction. These results demonstrated that the neuroprotective effects of honokiol and magnolol may be related to their anti-oxidative actions and antagonism of excitotoxicity induced by excitatory amino acids, suggesting that bo...Continue Reading

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Citations

Mar 13, 2009·Archives of Pharmacal Research·Yung-Hsiang ChenMing-Tsung Lai
Nov 6, 2010·Archives of Pharmacal Research·Young Choong Kim
Dec 27, 2007·Acta Pharmacologica Sinica·Byung Hun Kim, Jae Youl Cho
Oct 17, 2009·Journal of Biomedical Science·Yi-Ruu LinMing-Huan Chan
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Mar 21, 2012·Journal of Neuroinflammation·Deepak Kumar KaushikAnirban Basu
Apr 5, 2016·Pharmacognosy Reviews·Uorakkottil IlyasPunnooth Poonguzi Naseef
Sep 6, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyeon-Uk JeongHye Suk Lee
Apr 7, 2012·Journal of Pharmaceutical and Biomedical Analysis·Zhengjun Cheng
Nov 24, 2011·Neurochemistry International·Dong-Young ChoiMoon Soon Lee
Feb 1, 2011·Pharmacology & Therapeutics·Young-Jung LeeJin Tae Hong
Aug 18, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ying-Hsien KaoChao-Long Chen
Dec 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qun XuLing-Dong Kong
Sep 11, 2007·Life Sciences·Yi-Ruu LinMing-Huan Chan
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