Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo

Journal of Medicinal Food
Chung-Kwe WangYu-Chih Liang

Abstract

Vitis thunbergii var. taiwaniana (VTT) is a wild grape native to Taiwan, where it has been used as a folk medicine. In this study, we found that the branch and leaf ethanol extracts of VTT significantly inhibited the inducible nitric oxide (NO) synthase protein expression and NO production in BV2 microglia. Using primary neuronal cells, kainic acid (KA) significantly increased hydrogen peroxide production in a dose-dependent manner. All four ethanol extracts of VTT significantly decreased hydrogen peroxide production. However, only root and branch ethanol extracts were able to prevent the neuronal cell death induced by KA in vitro. In the animal study, administration of all four plant part extracts of VTT delayed the onset of seizure and decreased the hippocampus neuronal cell loss, and the neuroprotective activity could be ranked as follows: branch approximately leaf > root > trunk. The results suggest that VTT extracts have a potential to prevent neurodegeneration through the antioxidative activity by their ability to inhibit NO and hydrogen peroxide production.

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Citations

Apr 27, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chun-Hsu PanChieh-Hsi Wu
Apr 12, 2014·Journal of Medicinal Food·Ching-Fent TsaiChing-Chiung Wang
Oct 4, 2012·Drug and Chemical Toxicology·Shing-Sheng WuYu-Chih Liang
Jan 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Nur Shafika Mohd SairaziSiti Amrah Sulaiman
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Hong-Ming HsuFrank Chiahung Mao
Oct 23, 2019·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni Fm Strippoli

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Methods Mentioned

BETA
electrophoresis
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad Prism

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