Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Minoru FujikiHidenori Kobayashi

Abstract

In this study we evaluated the effect of donepezil on the neurodegeneration and behavioral impairments induced by mild traumatic brain injury (MTBI). Donepezil is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. Donepezil was given orally to rats subjected to MTBI. Treatment with a single oral dose of donepezil (12mg/kg) immediately after injury significantly attenuated MTBI-induced neuronal death and cognitive impairment as measured by preservation of neurons in the CA1 region of the hippocampus and a water maze test respectively. However, these neuroprotective effects were prevented by concomitant injection of mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection is mediated by nAChR activation.

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Citations

Jul 26, 2012·Journal of Neurotrauma·Claudia S RobertsonH Julia Hannay
Mar 5, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M MéndezJ L Arias
Dec 15, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Percival H PangilinanJoseph Edward Hornyak
Oct 14, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cornelius K DonatPeter Brust
Nov 15, 2011·Neuroscience Letters·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Nov 20, 2012·Chemico-biological Interactions·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Nov 4, 2017·International Journal of Molecular Sciences·Jeong Hyun JeongSang Won Suh
Jan 22, 2019·Journal of Neurotrauma·Colleen N BodnarAdam D Bachstetter

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