Neuroprotective and neuro-survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and mitochondrial uncoupling protein -2(UCP-2)

Medical Hypotheses
Afrah SepehrSepideh Safari

Abstract

Methamphetamine is a behavioral psychostimulant that has a high potential for misuse and induction of neurotoxicity. Safinamide is a novel inhibitor of monoamine oxidase B (MAOB) with neuroprotective properties. Methamphetamine abuse causes dysfunction in the respiratory chain of the mitochondria, but the specific signaling mechanism and role of the uncoupling protein-2(UCP-2) remain unclear. As we know, some indirect evidence indicates that neurodegeneration can be caused by inhibition of the brain-derived neurotrophic factor (BDNF) receptor, TrkB and its downstream signaling pathway, such as the PGC-1α protein. Neuroprotective strategies and approaches to the management, treatment or prevention of methamphetamine-induced neurodegeneration by modulating BDNF / TrkB / PGC-1α-UCP-2 can be considered as novel therapeutic approaches to these psychostimulant neurochemical and neurobehavioral approaches. Previous studies have shown that safinamide, a monoamine oxidase-B (MAOB) inhibitor, can function as a neuroprotective agent and inhibit the neurodegenerative process especially in Parkinson's disease but its impact on other neurodegenerative processes and drug-induced neurotoxicity remain unclear. Although there is some evidence th...Continue Reading

References

Jul 29, 2000·European Journal of Pharmacology·C HaroldB Yamamoto
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Subramaniam JayanthiJean Lud Cadet
Jun 11, 2004·Journal of Neurochemistry·Anna MireckiStephen J Kish
Nov 16, 2004·Annals of the New York Academy of Sciences·Masato AsanumaNorio Ogawa
Oct 13, 2006·Neurology·C CacciaR G Fariello
Dec 2, 2008·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Ahmed ElkashefJari Tiihonen
Mar 31, 2009·Brain Research Reviews·Irina N Krasnova, Jean Lud Cadet
Aug 22, 2009·Neurochemical Research·Bessy ThrashMuralikrishnan Dhanasekaran
Nov 10, 2009·International Review of Neurobiology·Jean Lud Cadet, Irina N Krasnova
Jan 19, 2010·Pharmacological Reports : PR·Bessy ThrashMuralikrishnan Dhanasekaran
Feb 6, 2013·Asian Journal of Psychiatry·Chirayu D PandyaAnilkumar Pillai
Mar 23, 2013·Brain : a Journal of Neurology·Damineh MorsaliKenneth J Smith
Mar 1, 2008·Expert Review of Clinical Pharmacology·David A Gorelick
Jul 17, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Joachim D UysDanyelle M Townsend
May 1, 1998·Annals of the New York Academy of Sciences·Subramaniam JayanthiJean Lud Cadet
Jan 18, 2018·Drug Discovery Today·Fábio G TeixeiraAntónio J Salgado
Feb 15, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Francesca ManciniCristoforo Comi
Mar 28, 2018·Ageing Research Reviews·Jianjun LvYang Yang
Mar 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pawel Licznerski, Elizabeth A Jonas
Apr 13, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anna V SharikovaSupriya D Mahajan
Jul 22, 2018·Neurochemical Research·Md Mahdi Hasan-OliveLinda H Bergersen
Aug 18, 2018·Molecular Neurobiology·Bruno Lima GiacobboErik F J de Vries
Sep 11, 2018·Frontiers in Neurology·Julien Delezie, Christoph Handschin
Dec 14, 2018·Journal of Neuroinflammation·Fatemeh ShaerzadehHabibeh Khoshbouei
Apr 16, 2019·Frontiers in Neuroscience·Viviane José de Oliveira BristotAderbal Silva Aguiar
May 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sashaina E FanibundaVidita A Vaidya

❮ Previous
Next ❯

Citations

Jun 30, 2021·Experimental Neurology·Subramaniam JayanthiJean Lud Cadet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved