Neuroprotective and neurochemical properties of mint extracts

Phytotherapy Research : PTR
Víctor LópezMaria Isabel Calvo

Abstract

Mints are aromatic plants with a tradition as medicinal remedies and culinary herbs. With the aim of investigating potential central nervous system (CNS) activities of traditional medicinal plants, four species and one hybrid of the genus Mentha (M. aquatica, M. longifolia, M. pulegium, M. suaveolens and M. x piperita) were selected. Methanolic extracts of the plants were tested for protective effects against hydrogen-peroxide-induced toxicity in PC12 cells, antioxidant activity (by ABTS and X/XO methods) and neurochemical properties (MAO-A inhibition, AChE inhibition and affinity to the GABA(A) receptor). Mentha x piperita and Mentha aquatica produced significant (p < 0.05) protection of the PC12 cells against oxidative stress. All the plants exhibited antioxidant and MAO-A inhibitory activities, M. x piperita being the most active. M. aquatica showed the highest affinity to the GABA(A)-receptor assay. Results demonstrate that mints might have effect on the CNS.

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Citations

Apr 28, 2010·Plant Foods for Human Nutrition·Víctor LópezMaria Isabel Calvo
Jun 8, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Sandra M BarbalhoClaudemir Gregório Mendes
Jul 29, 2016·PloS One·Sandra JiménezMaría Jesús Rodríguez-Yoldi
Mar 17, 2020·Phytotherapy Research : PTR·Ganesan Mahendran, Laiq-Ur Rahman
May 20, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mijat BožovićRino Ragno
Sep 27, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Dahee SonEunsun Jung
Sep 27, 2018·Frontiers in Plant Science·Pooja Singh, Abhay K Pandey
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Elena Todirascu-CiorneaAbdel Nasser B Singab
Jul 31, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Giovanna Felipe Cavalcante E CostaTales Alexandre Aversi-Ferreira
Aug 7, 2019·Antioxidants·Olívia R PereiraSusana M Cardoso
Mar 2, 2021·Frontiers in Psychiatry·Mohamed H AlegiryAbdelfatteh El Omri
Jun 19, 2021·Natural Product Research·Luciana Bitencourt de SouzaAna Lucia Tasca Gois Ruiz
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