Neuroprotective and neurotoxic effects of cyclosporine A on transient focal ischemia in mdr1a knockout mice

European Journal of Pharmacology
Michihiro MurozonoYasuo Watanabe

Abstract

The proper dose of cyclosporine A as a neuroprotective agent was investigated using the middle cerebral artery occlusion model of mdr1a knockout mice. After a 30-min occlusion period, reperfusion was performed and the vehicle or cyclosporine A (1 mg/kg or 10 mg/kg x 2) was intraperitoneally administered to each animal model group. Forty eight hours after reperfusion, infarction volume in the 1 mg/kg cyclosporine A group was significantly less than that seen in the vehicle group, although, in the high dose cyclosporine A group, infarction volumes were significantly higher than those seen in the vehicle group. These results demonstrate that cyclosporine A shows not only anti-ischemic effects, but also neurotoxic effects depending on the dosage penetrating into the brain.

References

Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Dec 1, 1985·Journal of Neurochemistry·W T Cefalu, W M Pardridge
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
May 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KitagawaT Yanagihara
May 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A C NgaiH R Winn
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S MatsumotoT Wieloch

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Citations

Mar 12, 2009·Neurochemical Research·Michihiro MurozonoYasuo Watanabe
Jul 11, 2018·Acute Medicine & Surgery·Shohei MatsumotoYasuo Watanabe

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