Abstract
The proper dose of cyclosporine A as a neuroprotective agent was investigated using the middle cerebral artery occlusion model of mdr1a knockout mice. After a 30-min occlusion period, reperfusion was performed and the vehicle or cyclosporine A (1 mg/kg or 10 mg/kg x 2) was intraperitoneally administered to each animal model group. Forty eight hours after reperfusion, infarction volume in the 1 mg/kg cyclosporine A group was significantly less than that seen in the vehicle group, although, in the high dose cyclosporine A group, infarction volumes were significantly higher than those seen in the vehicle group. These results demonstrate that cyclosporine A shows not only anti-ischemic effects, but also neurotoxic effects depending on the dosage penetrating into the brain.
References
Jul 1, 1990·Molecular and Cellular Biology·S I HsuS B Horwitz
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Aug 1, 1985·Transplantation·J F Gerkens, A J Smith
Dec 1, 1985·Journal of Neurochemistry·W T Cefalu, W M Pardridge
Oct 1, 1995·The Journal of Clinical Investigation·A H SchinkelP Borst
Nov 16, 1994·Biochemical Pharmacology·A SakataA Tsuji
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Mar 1, 1996·Neurosurgery·E S ConnollyD J Pinsky
Nov 1, 1996·Annals of Neurology·J W McDonaldD W Choi
May 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KitagawaT Yanagihara
May 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A C NgaiH R Winn
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S MatsumotoT Wieloch
Aug 28, 1999·Life Sciences·H ShutoR Oishi
Mar 7, 2001·Nature Medicine·T SakaiR Fässler
Dec 7, 2002·Life Sciences·Shohei MatsumotoTadeusz Wieloch
Citations
Oct 6, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Bozena GabryelAndrzej Malecki
Mar 12, 2009·Neurochemical Research·Michihiro MurozonoYasuo Watanabe
May 20, 2011·Neuropeptides·Mohamed M OsmanCesar V Borlongan
Oct 3, 2006·Neurobiology of Disease·Sherif BoulosNeville W Knuckey
Oct 3, 2019·Neurocritical Care·Xiang ZhouZhiTian Tan
Sep 25, 2016·Journal of Molecular Neuroscience : MN·Farinoosh FakharniaAbolhassan Ahmadiani
Jul 11, 2018·Acute Medicine & Surgery·Shohei MatsumotoYasuo Watanabe
Oct 31, 2017·Journal of Pharmacological Sciences
Mar 10, 2020·Experimental Neurology·Austin C BoeseJean-Pyo Lee