Neuroprotective compounds isolated from Cynanchum paniculatum

Archives of Pharmacal Research
Jin Bae WeonChoong Je Ma

Abstract

Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeonol (1), 4-acetylphenol (2), 2,5-dihydroxy-4-methoxyacetophenone (3), 2,3-dihydroxy-4-methoxyacetophenone (4), acetoveratrone (5), 2,5-dimethoxyhydroquinone (6), vanillic acid (7), resacetophenone (8), m-acetylphenol (9) and 3,5-dimethoxyhydroquinone (10). The protective effect of compounds 1-10 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was evaluated. Among them, compound 4 showed a relatively effective protection of 47.55% (at 10 μM). This result suggested that compounds 4 had neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells.

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Citations

Nov 29, 2017·Frontiers in Plant Science·Mengyue GuoXiaohui Pang
Jul 24, 2020·Natural Product Research·Akram M KayedEl-Sayed M Elghaly
Jul 11, 2014·Biomolecules & Therapeutics·Jin Bae WeonChoong Je Ma
May 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lu HanChangcai Bai
Jun 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Shu-Yu YangMeng-Jen Lee

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