Neuroprotective Drugs in Infants With Severe Congenital Heart Disease: A Systematic Review

Frontiers in Neurology
Raymond StegemanManon J N L Benders

Abstract

Background: Perinatal and perioperative brain injury is a fundamental problem in infants with severe congenital heart disease undergoing neonatal cardiac surgery with cardiopulmonary bypass. An impaired neuromotor and neurocognitive development is encountered and associated with a reduction in quality of life. New neuroprotective drugs during surgery are described to reduce brain injury and improve neurodevelopmental outcome. Therefore, our aim was to provide a systematic review and best-evidence synthesis on the effects of neuroprotective drugs on brain injury and neurodevelopmental outcome in congenital heart disease infants requiring cardiac surgery with cardiopulmonary bypass. Methods: A systematic search was performed in PubMed, Embase and the Cochrane Library (PRISMA statement). Search terms were "infants," "congenital heart disease," "cardiac surgery," "cardiopulmonary bypass," and "neuroprotective drug." Data describing the effects on brain injury and neurodevelopmental outcome were extracted. Study quality was assessed with the Cochrane Risk of Bias Tool. Two reviewers independently screened sources, extracted data and scored bias. Disagreements were resolved by involving a third researcher. Results: The search identif...Continue Reading

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Citations

Dec 30, 2020·Pediatric Cardiology·Melinda BarkhuizenAntonio W D Gavilanes
Feb 16, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Debasis DasKuntal Roy Chowdhuri

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Clinical Trials Mentioned

NCT03162653

Software Mentioned

Cochrane Risk of Bias Tool
Cochrane Risk of Bias
Scopus

Related Concepts

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Brain Injury & Trauma

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