Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Chao GuoAidong Wen

Abstract

Sodium danshensu (SDSS), the sodium salt of danshensu (DSS), has the same pharmacological effects as DSS. In the present study, we aimed to investigate the neuroprotective effect and possible mechanism of SDSS against cerebral ischemic/reperfusion injury. Sprague-Dawley rats were randomly divided into four groups: sham, control, 30 mg/kg and 60 mg/kg SDSS. Cerebral ischemia was induced by 2 h of middle cerebral artery occlusion (MCAO). Neurological functional deficits were evaluated according to the modified neurological severity score (mNSS); cerebral infarct volume and histological damage were measured by TTC or H-E staining. In addition, the number of apoptotic cells and caspase 3/7 activity were assessed by TUNEL or Caspase-Glo assay. And the expression of apoptosis-regulatory proteins and the PI3K/Akt pathway were investigated by western blotting. Our results showed that treatment with SDSS for 5 days after MCAO remarkably improved neurologic deficits and survival rate, reduced infarct volume and the number of dead neurons. SDSS also decreased the number of apoptotic cells, regulated the expression of Bcl-2 and Bax, and increased the ratio of Bcl-2/Bax. Further study revealed that treatment with SDSS also increased the lev...Continue Reading

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Citations

Dec 27, 2015·Translational Stroke Research·Carlo CaltagironeUNKNOWN Stroke Study Group
May 20, 2016·Neuromolecular Medicine·Joonki KimThiruma V Arumugam
Jun 2, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jingwei TianFu Liu
Nov 4, 2016·Oxidative Medicine and Cellular Longevity·Cheng-Chieh ChangYu-Chiang Hung
Jan 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Xinhua ZhouMaggie Pui Man Hoi
Aug 15, 2020·Neurochemical Research·Wanting LiYunman Li
Jan 30, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Guangxu XiaoYan Zhu
Oct 27, 2020·Frontiers in Endocrinology·V Bharath KumarMu-Kuan Chen

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