PMID: 11907175Mar 22, 2002Paper

Neuroprotective effect of (2S,3S,4R)-N"-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats

The Journal of Pharmacology and Experimental Therapeutics
Ki Whan HongSung-eun Yoo

Abstract

This study shows the preventive effect of KR-31378 [(2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine] against cerebral infarct via antioxidant and antiapoptotic actions evoked by subjecting rats to 2 h of occlusion of the left middle cerebral artery followed by 24 h of reperfusion. The brain infarct zone in the cortex and striatum of the left hemisphere was consistently identified in the cortex and striatum of the left hemisphere. The infarct area was significantly reduced after three intraperitoneal administrations of 10, 30, or 50 mg/kg KR-31378 at 5 min, 4 h, and 8 h after the completion of 2 h of ischemia. Treatment with KR-31378 (30 or 50 mg/kg) significantly reduced the increase in the number of terminal deoxynucleotidyl transferase dUTP nick-end labeling positive cells as well as strongly suppressed the laddered feature of DNA fragmentation in the lateral cortical tissue corresponding to the penumbra. The findings of samples from penumbral zone, which showed markedly reduced Bcl-2 protein level and increased Bax protein and cytochrome c release, were wholly reversed by treatment with KR-31378. In conclusion, postischemic treatment with KR-31378 provide...Continue Reading

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Citations

Aug 26, 2003·Archives of Pharmacal Research·Young Taek Sohn, Bo Ye Park
Jan 6, 2006·Archives of Pharmacal Research·Mi-Young KimYi-Sook Jung
Nov 12, 2003·Archives of Pharmacal Research·Tae Cheon JeongHye Suk Lee
Dec 11, 2007·Molecular Neurobiology·Venkata Prasuja NakkaRam Raghubir
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Ran WonNak-Won Sohn
Feb 21, 2008·The Journal of Pharmacy and Pharmacology·Liu YimingZeng Fandian
Jun 10, 2004·The Journal of Veterinary Medical Science·Takayuki NakajimaKoichi Kawahara
Dec 2, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chang-Ha LeeWon Gon Kim

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