Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms

Life Sciences
Mona K TawfikSawsan A Zaitone

Abstract

Painful diabetic neuropathy (PDN) is one of the most frequent complications of diabetes and the current therapies have limited efficacy. This study aimed to study the neuroprotective effect of duloxetine, a serotonin noradrenaline reuptake inhibitor (SNRI), in a mouse model of diabetic neuropathy. Nine weeks after developing of PDN, mice were treated with either saline or duloxetine (15 or 30 mg/kg) for four weeks. The effect of duloxetine was assessed in terms of pain responses, histopathology of sciatic nerve and spinal cord, sciatic nerve growth factor (NGF) gene expression and on the spinal expression of astrocytes (glial fibrillary acidic protein, GFAP) and microglia (CD11b). The present results highlighted that duloxetine (30 mg/kg) increased the withdrawal threshold in von-Frey test. In addition, both doses of duloxetine prolonged the licking time and latency to jump in the hot-plate test. Moreover, duloxetine administration downregulated the spinal expression of both CD11b and GFAP associated with enhancement in sciatic mRNA expression of NGF. The current results highlighted that duloxetine provided peripheral and central neuroprotective effects in neuropathic pain is, at least in part, related to its downregulation in ...Continue Reading

Citations

Mar 23, 2019·Chemical Biology & Drug Design·Kinga SałatNatalia Malikowska-Racia
Sep 21, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yuya KawaraiSeiji Ohtori
Oct 28, 2019·Reviews in Endocrine & Metabolic Disorders·Estelle Grasset, Remy Burcelin
May 18, 2020·Neurotoxicity Research·Wanli GaoDing Wang
Oct 3, 2020·Best Practice & Research. Clinical Anaesthesiology·Ivan UritsOmar Viswanath
May 18, 2019·Thérapie·Hichem BouchenakiClaire Demiot

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