Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation

The Journal of Biological Chemistry
Peter E LonerganM A Lynch

Abstract

Exposure to irradiation leads to detrimental changes in several cell types. In this study we assessed the changes induced in hippocampus by exposure of rats to whole body irradiation; the findings reveal that irradiation leads to apoptotic cell death in hippocampus, and as a consequence, long term potentiation in perforant path-granule cell synapses is markedly impaired. The evidence is consistent with the view that irradiation induced an increase in reactive oxygen species and that this leads to stimulation of the stress-activated protein kinase, JNK, and activation of the transcription factor, c-Jun. Consequent upon activation of JNK, a cascade of cell signaling events was stimulated that ultimately resulted in apoptosis, as suggested by parallel increases in cytochrome c translocation, caspase-3 activation, poly(ADP-ribose) polymerase cleavage, and terminal dUTP nick-end labeling staining. Treatment of rats with eicosapentaenoic acid inhibited the irradiation-induced increase in reactive oxygen species production and the subsequent cellular signaling events, suggesting that oxidative stress triggered apoptotic cell death in the hippocampus of rats exposed to irradiation. Significantly, when the compromise in cell viability i...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P NeedlemanH Sprecher
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Apr 1, 1991·Biochemical Society Transactions·M J Finnen, C R Lovell
Nov 24, 1995·Science·Z XiaM E Greenberg
Jan 1, 1994·International Journal of Radiation Biology·P A Riley
Dec 1, 1993·The Journal of Comparative Neurology·S A Benkovic, J R Connor
Jan 1, 1993·Progress in Lipid Research·C Rice-Evans, R Burdon
Jan 12, 1996·The Journal of Biological Chemistry·Y R ChenT H Tan
Jun 28, 1996·The Journal of Biological Chemistry·Y Y LoT F Cruz
Oct 1, 1996·Current Opinion in Neurobiology·J C Martinou, R Sadoul
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerJ M Lehmann
Jul 4, 1997·The Journal of Biological Chemistry·J ParkE J Choi
Jan 8, 1998·Scandinavian Journal of Immunology·E HallanJ Lømo
Apr 30, 1998·Current Opinion in Cell Biology·Y T Ip, R J Davis
Jun 20, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A SmithG Perry
Aug 28, 1998·Science·D R Green, J C Reed
Sep 2, 1998·Progress in Neurobiology·D A Pelligrino, Q Wang
Sep 28, 1998·The European Journal of Neuroscience·E GahtanM Segal
Mar 17, 1999·Biochimica Et Biophysica Acta·G A Cortopassi, A Wong
Apr 2, 1999·Brain Research. Molecular Brain Research·Y KumagaeC A Miller
Apr 14, 1999·Cell Death and Differentiation·B ZhivotovskyS Orrenius
Dec 1, 1999·Cell Death and Differentiation·E A SleeS J Martin
Jan 6, 2000·Current Medical Research and Opinion·H HayashiT Amakawa

❮ Previous
Next ❯

Citations

Sep 6, 2007·Cell and Tissue Research·Marta Andres-MachJohn R Fike
Aug 9, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Mustafa SarsilmazOmer Akyol
Jan 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregor E BergerPatrick D McGorry
Jun 9, 2006·Theoretical Biology & Medical Modelling·Subburaj Kannan
Aug 22, 2007·The British Journal of Radiology·W ZhaoM E Robbins
Jun 17, 2006·International Review of Psychiatry·Gregor E BergerG Paul Amminger
Nov 29, 2007·Expert Opinion on Investigational Drugs·Edward C Stack, Robert J Ferrante
Aug 23, 2007·Journal of Neurochemistry·Aedín M MinogueMarina A Lynch
Mar 11, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Christoph U CorrellBarbara A Cornblatt
Jun 28, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Undurti N Das
Nov 2, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M LaasonenV Virsu
Apr 25, 2006·Free Radical Biology & Medicine·Anisa JahangiriEdward J McMurchie
Jun 25, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·F TrevizolM E Bürger
Apr 13, 2010·Neurobiology of Aging·Thelma R CowleyMarina A Lynch
May 4, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Undurti N Das
Mar 21, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M LaasonenM-L Haapanen
Feb 18, 2005·Journal of Lipid Research·Roger M Lane, Martin R Farlow
Mar 30, 2011·Toxicology and Industrial Health·Ismail ZararsizSadik Sogut
Dec 11, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Phil Hyu LeeMan-Jeong Paik
Nov 29, 2013·Human Psychopharmacology·Isabelle BauerDavid Crewther
May 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rohit A SinhaSanghamitra Bandyopadhyay
Nov 21, 2019·Journal of Neurochemistry·Merja JoensuuFrédéric A Meunier
May 6, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marianne Haag

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