Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer's Disease

Evidence-based Complementary and Alternative Medicine : ECAM
Chen LiangYue-Qin Zeng

Abstract

Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. Fagopyrum dibotrys is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of Fagopyrum dibotrys extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of Aβ peptide were evaluated in vitro. After 9-month treatment, FDE exhibited multifunctional properties on Aβ-related pathologies, which cleaned Aβ deposits in the brain and decreased Aβ burden in the plasma, inhibited microhaemorrhage, and reduced reactive microglia in APP/PS1 transgenic mice and also promoted Aβ fibrils disaggregation and inhibited neurotoxicity induced by Aβ in SH-SY5Y cells. These results highlighted that FDE is an AD type pathology modulator with therapeutic potential against AD.

References

May 5, 2001·Biomolecular Engineering·J L JankowskyD R Borchelt
Jun 12, 2002·The Journal of Biological Chemistry·Karie N DahlgrenMary Jo LaDu
Sep 9, 2006·Brain Research Reviews·Petrea FridNatalija Popovic
Jan 16, 2007·Journal of Neuroimmunology·Michael T Heneka, M Kerry O'Banion
Oct 22, 2008·Genes & Nutrition·David VauzourJeremy P E Spencer
Nov 7, 2009·The American Journal of Pathology·Tsuyoshi HamaguchiMasahito Yamada
Jan 29, 2010·The New England Journal of Medicine·Henry W Querfurth, Frank M LaFerla
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kanti Bhooshan Pandey, Syed Ibrahim Rizvi
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Jiang WangXin-Fu Zhou
Dec 23, 2011·Annals of Neurology·Anand Viswanathan, Steven M Greenberg
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simantini GhoshM Kerry O'Banion
May 25, 2013·Clinical Pharmacokinetics·Christian UdeMario Wurglics
May 23, 2014·Frontiers in Neurology·Yue-Qin ZengXin-Fu Zhou
Oct 16, 2014·Biochimica Et Biophysica Acta·Giulio Maria PasinettiLauren Dubner
Dec 2, 2014·Expert Opinion on Therapeutic Targets·Patrick L McGeer, Edith G McGeer
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer

❮ Previous
Next ❯

Citations

Nov 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiang ZhangLinfang Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
column chromatography
Assay
Fluorescence
PCR
ELISA
Transgenic

Software Mentioned

SPSS

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.