Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice

International Journal of Biological Macromolecules
Selvaraju MeenakshiThangavel Balasubramanian

Abstract

Fucoidan is one of the dominant sulfated polysaccharide which was extracted from the brown seaweed Turbinaria decurrens. In the behavioral study mice treated with fucoidan showed better response than the MPTP treated mice. Antioxidants and dopamine level has been increased in the fucoidan treated mice when compared to MPTP induced mice. In Immunohistochemistry, the increase of TH positive cells in the fucoidan treated group is correlated with the TH protein levels in substantia nigra and corpus striatum. The increase is greater than the content of dopamine and DOPAC, which may be explained that the dopaminergic terminals are more sensitive to MPTP toxicity and therefore are more severely damaged than the dopaminergic cell bodies. In immunoblotting TH and DAT was used, both the antibodies expression in MPTP was reduced and reversed in other groups. From the results it was conformed that the fucoidan has a neuroprotective effect without any side effects.

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Citations

Oct 12, 2019·Marine Drugs·Helen J FittonSamuel N Karpiniec
Jul 11, 2019·Polymers·Joanne Katherine Talens ManlusocPo-Wei Tsai
Jul 3, 2019·Biology·George A McCanneySusan C Barnett
Mar 4, 2021·Marine Drugs·Leonel Pereira, Ana Valado
Mar 17, 2021·Critical Reviews in Food Science and Nutrition·Devina LobineMohamad Fawzi Mahomoodally
May 25, 2020·International Journal of Biological Macromolecules·Ramar ManikandanNarayanasamy Marimuthu Prabhu
Jul 28, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rajan KumarLeander Corrie

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